Acetyl tetrapeptide-5 (CAS: 820959-17-9) is an artificially synthesized low molecular weight functional oligopeptide with a small molecular particle size and excellent cutaneous tissue penetration ability. It can quickly penetrate the superficial cortex around the ocular tissues and exert biological activity. It is a highly adaptable specialized active component in the ocular tissues integumentary maintenance system. This substance, with its unique biological pathway, has three core exclusive characteristics in the field of eye repair. It can quickly dissolve physiological eye swelling in the morning, accurately improve circulatory dark circles, and adapt to thin, tender, and fragile cutaneous tissue around the ocular tissues. It also has quantifiable short-term and long-term integumentary maintenance effects, making it a core component for targeted solutions to fatigue ocular tissues problems in modern populations.
product Description
Acetyl Tetrapeptide-5 COA
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| Certificate of Analysis | ||
| Compound name | Acetyl tetrapeptide-5 | |
| Grade | Pharmaceutical grade | |
| CAS No. | 820959-17-9 | |
| Quantity | Customized | |
| Packaging standard | Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.36% |
| Loss on drying | ≤1.0% | 0.24% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.37% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place, 2-8°C | |
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Acetyl tetrapeptide-5 price rapid morning eye swelling relief and instant eye soothing performance
Different from the slow acting conditioning mode of most integumentary maintenance ingredients, the core advantage of acetyl tetrapeptide 5 is its fast onset of action, which can effectively improve the sudden swelling of eye bags and swelling around the ocular tissues in the morning. It is a typical instant effect eye integumentary maintenance component and is suitable for daily emergency eye care scenarios.
01.Exclusive biological pathway, quickly blocking edema formation
This ingredient can quickly reach the capillary periphery of the ocular dermis through transdermal penetration, competitively binding to the active site of angiotensin converting enzyme, downregulating the catalytic efficiency of the enzyme, slowing down the conversion rate of angiotensin to its original active state, thereby relieving the abnormal contraction state of ocular microvessels, reducing the static water pressure in the lumen, synchronously strengthening the connection tightness between endothelial cells, significantly reducing the probability of plasma and tissue fluid leaking out of the interstitium, and blocking the formation logic of abnormal accumulation of ocular tissue fluid from the physiological pathway source. At the same time, this ingredient can activate the transport activity of the superficial lymphatic network around the eye, accelerate the reflux rhythm of lymphatic fluid, quickly guide and metabolize excess interstitial water accumulated in the subcutaneous space, without the need for long-term cumulative maintenance cycles. A single application can intervene in the formation process of edema, and within a few hours, the intuitive effect of reducing eye swelling can be displayed, achieving the core function of rapid swelling reduction.
02.Adapting to multiple physiological edema scenarios
Its immediate anti-inflammatory effect can accurately cover various non organic causes of eye swelling in daily life, and the adaptation scenarios are very diverse. This ingredient can be used to improve the eye edema caused by excessive drinking water before sleep at night, water sodium retention caused by high salt diet, edema caused by the disturbance of circadian rhythm and insufficient sleep, periocular muscle tension caused by long-term close eye use, microcirculation stasis type bulge, and the increase of circulatory permeability caused by seasonal cutaneous tissue mild stress and temporary vulnerability of barriers. Compared to ordinary moisturizing and soothing ingredients that can only act on the surface of the cutaneous tissue and are difficult to reach the core causes of edema, this ingredient can directly enter the physiological pathway of edema regulation, quickly restore the swollen and bloated state around the ocular tissues, and quickly restore the smooth contour lines of the ocular tissues. Applying it in the morning integumentary maintenance session can efficiently alleviate morning eye fatigue, improve the haggard appearance caused by eye swelling, and provide a smoother cutaneous tissue state for subsequent eye makeup.
Targeted unblocking of peripheral circulation, precise improvement of circulatory dark circles and dark circles under the ocular tissues
In the field of dark circles repair, acetyl tetrapeptide-5 has strong targeting ability and only exerts repairing effect on circulatory dark circles. It has no intervention effect on dark circles caused by pigment deposition, bone depression, and fat protrusion. It is an exclusive repairing component for circulatory dark circles around the ocular tissues.
Accurately matching the pathogenesis of circulatory type dark circles
The core cause of circulatory type dark circles is the stagnation of capillary circulation and obstruction of venous blood return at the edge of the eye, resulting in low oxygen content in superficial blood vessels around the eye. This leads to a bluish gray and dark visual appearance under the thin and tender cutaneous tissue layer, which is a temporary cutaneous tissue problem caused by abnormal circulation and metabolism, rather than stubborn dullness caused by pigment deposition, perfectly matching the target of this ingredient.
Clearing circulation blockages and gradually reducing dark and dark spots
This ingredient can activate the circulation vitality of peripheral microvessels in the ocular tissues, unblock blocked circulatory pathways, accelerate local congestion metabolism and blood oxygen supply, and gradually improve the dark and dark spots formed by superficial circulatory blockages. By continuously regulating the microcirculation around the ocular tissues and weakening the dull appearance caused by circulatory translucency, the cutaneous tissue around the ocular tissues gradually returns to transparency and uniformity, effectively solving the problem of circulatory dark circles caused by staying up late and tired eye use.
Suitable for thin and tender cutaneous tissue around the ocular tissues, with quantifiable stage specific integumentary maintenance effects
The eye area is the weakest part of the human cortex and the most fragile barrier structure. The distribution of sebaceous and sweat glands is scarce, and the tolerance to external active ingredients is extremely low, making it prone to discomfort such as redness and stinging. Acetyl tetrapeptide-5 has low sensitivity and mild properties, which can perfectly adapt to fragile cutaneous tissue around the ocular tissues. It has been verified by human testing that it has clear and quantifiable short-term and long-term integumentary maintenance effects.
Extremely low irritation properties, suitable for all cutaneous tissue eye care
This synthetic oligopeptide ingredient has stable and mild properties, without allergenic, inflammatory, or irritating characteristics, and will not damage the weak cutaneous tissue barrier structure around the ocular tissues or cause cutaneous tissue stress reactions. Whether it is healthy normal cutaneous tissue, fragile and thin cutaneous tissue, or sensitive cutaneous tissue with low tolerance, it can be safely used for daily eye care, and its adaptability far exceeds various highly active and effective integumentary maintenance ingredients.
Short term test results
Significant improvement in eye swelling within 15 days: Based on public clinical test data, users adhere to daily morning and evening application of eye integumentary maintenance products containing compliant concentrations of acetyltetrapeptide-5. Within a 15 day period, more than 70% of subjects' eye swelling problems have been significantly improved. The frequency of morning eye bubbles and temporary eye bag swelling has been significantly reduced, and eye swelling and fatigue have been effectively relieved. The short-term maintenance effect is intuitively visible.
Long term advanced effect
60 day comprehensive rejuvenation of the eye area. After regular application for 60 days, this ingredient can stabilize and regulate the microcirculation and tissue fluid metabolism around the ocular tissues. On the basis of stable swelling reduction effect, it gradually improves the chain problems caused by long-term edema accumulation, such as eye bag bulging, dull and dull around the ocular tissues, and slight cutaneous tissue relaxation. It comprehensively optimizes the cutaneous tissue condition around the ocular tissues and achieves refined long-term maintenance.
Overall, Acetyl Tetrapeptide 5 has the advantages of instant and efficient anti-inflammatory ability, targeted and precise repair of circulatory dark circles, as well as mild, safe, and quantifiable maintenance characteristics, which accurately fit various fatigue eye problems caused by contemporary lifestyle disorders. Its low sensitivity and adaptability make it suitable for fragile cutaneous tissue around the ocular tissues. The layered and progressive stage based integumentary maintenance effect also makes it a highly targeted core active ingredient in refined eye care, providing a scientific and efficient repair solution for swollen, dark and dull cutaneous tissue around the ocular tissues.
References
Liu Siyao, Zhou Min Application and efficacy evaluation of functional oligopeptides in ocular cutaneous tissue repair [J]. Cosmetics Industry, 2023, 36 (06): 78-82
Park J, Lee S. Clinical evaluation of synthetic tetrapeptide on periorbital edema and circulatory dark circles[J]. Cosmetic Science and Technology, 2024,11(2):45-51.
Zhao Xinran Research on the Adaptation Mechanism and integumentary maintenance Value of Low Sensitivity Active Peptides for Weak cutaneous tissue[J]. Daily Chemical and Cosmetics Research, 2024, 03:39-43
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