Glutathione Liposomal Capsules

Glutathione Liposomal Capsules are a novel dietary supplement that encapsulates glutathione (GSH) in liposomes. The core principle is to use the double-layer phospholipid structure of liposomes to simulate cell membranes, and to protect glutathione from damage by gastric acid and digestive enzymes through nanoscale encapsulation technology, significantly improving its bioavailability. Traditional glutathione supplements are easily degraded by gastric acid after oral administration, resulting in an absorption rate of less than 10%, while liposome technology can increase the absorption rate to 60% -80%, achieving efficient delivery. Liposomes are composed of phospholipid bilayers, which are highly similar in structure to the cell membrane. This similarity allows them to fuse with the cell membrane and directly release glutathione into the cell. This process bypasses the complex pathway of traditional oral supplements that need to be absorbed through the intestine, lymphatic circulation, and then enter the bloodstream, significantly shortening the action time and reducing metabolic losses. The phospholipids in liposome capsules are usually derived from soybean or sunflower phospholipids, and their bilayer structure not only protects GSH from digestive system damage, but also promotes cellular uptake through membrane fusion mechanism. Some high-end products may add specific phospholipids (such as phosphatidylcholine) to enhance targeting, such as prioritizing delivery to liver or brain tissue.

We not only provide pure powder and capsules, but also other dosage forms. If necessary, please contact our sales team.

 

Our products

 

Pure Glutathione Powder

The Best Glutathione Injection

Glutathione Liposomal Tablets

Glutathione Liposomal Capsules

Liposomal Glutathione Drops

Liposomal Glutathione Spray

Glutathione COA

The core principle of Glutathione Liposomal Capsules is to use the double-layer phospholipid structure of liposomes to encapsulate glutathione (GSH), forming a nanoscale carrier. Liposomes have a similar structure to cell membranes and can protect GSH from damage by gastric acid and digestive enzymes, significantly enhancing its bioavailability. Traditional oral GSH supplements are easily degraded into amino acids in gastric acid environment, with an absorption rate of less than 10%, while liposome technology can increase the absorption rate to 60% -80%, achieving efficient delivery.

Core component

Reduced Glutathione Liposomal Capsules (L-Glutathione):As an active ingredient, high-purity (≥ 98%) reduced GSH should be selected to avoid interference from oxidized GSH (GSSG). The dosage is usually 250-500mg per capsule, which needs to be adjusted according to the target population (such as anti-aging, liver support, or immune regulation).
Phospholipid complex:Commonly used soybean or sunflower phospholipids require a phosphatidylcholine (PC) content of ≥ 60% to ensure the stability of the liposome structure. Some high-end formulas may add specific phospholipids (such as phosphatidylethanolamine, PE) to enhance targeting.

Auxiliary component

Stabilizers:Glycerol (10% -15%) is used to maintain the flexibility of the bilayer structure of liposomes and prevent particle aggregation.
antioxidant:Vitamin E (0.1% -0.5%) or alpha lipoic acid (0.05% -0.1%) can inhibit GSH oxidation and extend product shelf life.
Penetration enhancers:Polysorbate-20 (Tween-20, 1% -2%) can enhance the fusion ability between liposomes and cell membranes, and improve absorption efficiency.
preservative:Potassium sorbate (0.05% -0.1%) or sodium benzoate (0.05% -0.1%) can be selected, but chemical compatibility with GSH must be ensured.

Capsule shell material

Gelatin capsules:Suitable for conventional formulas with low cost, but attention should be paid to the risk of allergies (such as those sensitive to beef or pork gelatin).
Plant Capsules (HPMC):Using hydroxypropyl methylcellulose as raw material, it is suitable for vegetarians and people with religious dietary restrictions, and has higher stability.

Phospholipid pretreatment

Dissolve and mix: Mix phospholipids (1.5% -2.0% w/w) with glycerol (15% w/w) and stir to dissolve at 40-50 ℃ to form a uniform phospholipid solution. If stabilizers or antioxidants need to be added, they can be added at this stage.
Ultrasonic treatment: Use an ultrasonic probe (20kHz, power 50-100W) to treat phospholipid solution for 10-15 minutes to reduce particle size and improve uniformity. This step can significantly improve the encapsulation efficiency of liposomes.

GSH encapsulation and liposome formation

Water phase preparation: Dissolve GSH (8.5% w/w) in deionized water (74.4% w/w), add penetration enhancers (such as Tween-20, 2.5% w/w) and preservatives (such as potassium sorbate, 0.1% w/w), and stir until completely dissolved.
Liposome formation: Slowly drop phospholipid solution into GSH aqueous phase while stirring at 300-500rpm to form colostrum. Subsequently, use a high-pressure homogenizer (10000-15000 psi) for 3-5 cycles to refine the particle size to 100-200nm.
Centrifuge and Purification: Separate unencapsulated GSH by ultracentrifugation (100000 × g, 1 hour), and collect the liposome suspension in the supernatant. This step can increase the encapsulation efficiency to over 80%.

Capsule filling and drying

Suspension adjustment: Add seasonings (such as citrus seed extract, 0.5% w/w) or sweeteners (such as sucralose, 0.01% w/w) as needed, and adjust the pH to 6.5-7.0.
Soft capsule filling: Use a rotary molding machine to fill the liposome suspension into soft capsules, with each capsule containing 250-500mg of GSH. Immediately seal after filling to prevent oxidation.
Hard capsule filling (optional): If hard capsules are selected, the liposome suspension needs to be freeze-dried into powder, and then mixed with excipients (such as microcrystalline cellulose) before filling. This method can extend the shelf life, but additional disintegrants (such as cross-linked carboxymethyl cellulose sodium, 3% -5%) need to be added.

Sterilization and packaging

Radiation sterilization:Sterilize the finished capsules using gamma rays (25kGy) to ensure that the microbial indicators meet the standards (such as total colony count<100 CFU/g, mold and yeast<10 CFU/g).
Light resistant packaging:Packaged in brown glass bottles or aluminum foil composite bags to prevent GSH oxidation caused by light exposure. Desiccant (such as silica gel) should be placed inside the packaging to control humidity below 10%.

 

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