Palmitoyl Hexapeptide-12

Palmitoyl hexapeptide-12 is a fat soluble signal peptide formed by covalently linking palmitic acid with the hexapeptide sequence Val Gly Val Ala Pro Gly (VGVAPG). Its CAS number is 171263-26-6, and it appears as a white or off white powder. It is a star active ingredient widely used in current mid to high end anti-aging skincare products.
As a professional brand focused on peptide raw material innovation, Kepetide relies on 20 years of solid-phase synthesis technology precipitation to launch high-purity products (purity ≥ 99%). After third-party testing and verification, the cytotoxicity EC50 is greater than 1000 μ g/mL, and the 24-hour stratum corneum permeability reaches 82.3%, which meets industry-leading standards in safety and transdermal efficiency.

Certificate of Analysis
Compound name	Palmitoyl hexapeptide-12
Grade	Pharmaceutical grade
CAS No.	171263-26-6
Quantity	60g
Packaging standard	PE bag+Al foil bag
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202601090058
MFG	Jan 9th 2026
EXP	Jan 8th 2029
Structure
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.47%
Loss on drying	≤1.0%	0.35%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.93%
Single impurity	<0.8%	0.31%
Total microbial count	≤750cfu/g	78
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	545ppm
Storage	Store in a sealed, dark, and dry place below 2-8°C

It as a Matrikine family signal peptide modified with palmitoyl, does not achieve temporary tightening through physical filling or surface stimulation. Instead, it targets the core driving factors of dermal aging and completes skin rejuvenation and remodeling from the root through a complete biological loop of "signal activation structure repair loss blockade". Its mechanism of action has been validated through multiple in vitro cell experiments and 3D artificial skin models, forming a triple precise action pathway that is different from ordinary anti-aging peptides.

 

After the skin enters the natural aging or photoaging stage, the activity of dermal fibroblasts gradually decreases with age, the cell proliferation rate slows down, and the transmission of endogenous signaling pathways is blocked, directly leading to a significant decline in the synthesis of type I and III collagen, which is also the core root cause of skin sagging and concavity.

Its palmitoyl ester soluble side chains can quickly penetrate the lipid bilayer barrier of the stratum corneum, with a permeability of 82.3% within 24 hours, far higher than the transdermal efficiency of ordinary water-soluble peptides.

 

After directly reaching the dermis layer, its hexapeptide core sequence can accurately recognize integrin receptors and TGF - β receptors on the surface of fibroblast membranes, triggering a cascade reaction of downstream ERK/MAPK signaling pathways and awakening dormant fibroblasts.

In vitro cell experiment data shows that after 72 hours of treatment at a concentration of 0.01%, the proliferation activity of fibroblasts can be increased by 127%, the secretion of type I collagen can be increased by 143%, and the synthesis of type III "young collagen" can be increased by 217%. It fully simulates the human body's own collagen synthesis regulation mechanism and does not pose a risk of abnormal collagen proliferation caused by external stimuli. Sensitive skin and fragile skin with medical art barriers can also safely tolerate it.

 

Many traditional anti-aging ingredients only focus on promoting collagen production, but ignore the relaxation problem caused by elastic fiber breakage: as photoaging accumulates, the elastic fibers in the dermis layer will gradually fragment and break, and the original intact elastic support network will have a large number of holes. Even if a large amount of collagen is supplemented, it cannot form orderly three-dimensional support, and the skin will still collapse and lose its rebound feeling.

It can specifically upregulate the gene expression of elastin and fibronectin, while activating the activity of lysyl oxidase LOXL2, guiding the ordered crosslinking of newly generated elastin monomers, and reassembling fragmented elastic fibers into a continuous and elastic three-dimensional network structure. 

28 day human clinical test data shows that after continuous use of a formula containing 0.05% Kepetide palmitoyl hexapeptide-12, the elastic fiber density of the subjects' skin increased by 39.6%, the skin extensibility increased by 19.7%, and the resilience increased by 23.4%. The originally relaxed facial contours can quickly restore a tight and elastic feeling, improving aging symptoms such as nasolabial folds and blurred jawline caused by elastic fiber breakage.

As a professional beauty peptide raw material brand targeting the global market, Kpetide relies on more than 20 years of peptide synthesis technology and a global service system to create a full chain raw material supply and technical support solution that adapts to international market rules for overseas cosmetics brands, cross-border OEM factories, and research institutions' procurement needs. Especially in high-value signal peptide categories such as Pal-Val-Gly-Ala-Pro-Gly-OH, Kpetide has formed an exclusive service advantage that combines compliance, stability, and flexibility.

1. International chemical regulations and certification system

The entire series of peptide raw materials from Kpetide strictly comply with the regulatory requirements of the global mainstream market. The  product has completed a full set of compliance qualifications: 

 

Having complete GMP level production workshop qualifications, certified by cGMP and ISO 22716 Good Manufacturing Practice for Cosmetics, and meeting the registration requirements of the EU REACH regulation, it can smoothly enter the market circulation of the 27 EU countries;

 

Each batch of palmitoyl hexapeptide-12 can provide a complete set of compliance documents in English, including COA analysis report, HPLC purity chromatogram, MS mass spectrometry identification report, microbiological detection report, heavy metal and residual solvent detection report, SDS safety data sheet, fully meeting the raw material filing requirements of the US FDA, EU CPNP, and ASEAN Cosmetics Association;

 

The product has also passed ECOCERT natural organic ingredient related indicator verification, with no animal derived ingredients or genetically modified ingredients, meeting the mainstream raw material standards of Clean Beauty in the European and American markets, and adapting to the formula positioning of high-end organic skincare brands.

2. Global supply chain and delivery capability

Kepetide has built a distributed warehousing and logistics network covering the world, completely solving the time pain points of overseas customers' peptide raw material procurement: 

 

There are regular spot warehouses in the core regions of North America and Europe, which can achieve local warehouse delivery within 48 hours according to their standard specifications, and can be delivered to core markets such as the United States and Germany within 3-5 working days, avoiding the risk of stockout caused by long-term cross-border transportation;

 

Support flexible ordering of all specifications, from 10mg scientific research samples, 100g small batch trial production packaging to ton level annual bulk orders can be undertaken. For small batch sample needs of small and medium-sized brands, they can be directly shipped from overseas local warehouses without lengthy international customs clearance processes;

 

We have a mature international logistics and customs clearance team that can assist customers in completing the entire process of import and export declaration, tariff compliance verification, and other procedures for peptide raw materials, avoiding cargo delays caused by incomplete information and significantly reducing the procurement communication costs for overseas customers.

1.Ligorio, C., Tavasoli, E., Karaman-Jurukovska, N., et al. (2025). Noninvasive Monitoring of Palmitoyl Hexapeptide-12 in Human Skin Layers: Mechanical Interaction with Skin Components and Its Potential Skincare Benefits. ACS Applied Bio Materials, 8(3), 2340-2355. https://doi.org/10.1021/acsabm.4c01816

2.Bjerke, D.L., Li, J., Gao, Y., et al. (2026). A framework for the safety evaluation of peptides in cosmetics. Current Research in Toxicology, 10, 100291. https://doi.org/10.1016/j.crtox.2026.100291

3.Kim, E.J., Park, S.Y., Lee, J.H., et al. (2017). PAL-12, a new anti-aging hexa-peptoid, inhibits UVB-induced photoaging in human dermal fibroblasts and 3D reconstructed human full skin model. Journal of Cosmetic Dermatology, 16(4), 521-529. https://doi.org/10.1111/jocd.12327

4.Zhang, Y., Wang, L., & Chen, H. (2021). TGF-β Activation by Palmitoyl Hexapeptide-12 Enhances Collagen Production. Journal of Investigative Dermatology, 141(5), 1120-1128.

5.Lee, H., Park, M., & Kim, S. (2019). Neurotransmitter Modulation by Peptides in Cosmetic Applications. Experimental Dermatology, 28(6), 689-695.

6.Lintner, K. (2002). Signal peptides in skin regeneration: The matrikine concept. International Journal of Cosmetic Science, 24(3), 167-176.

Kawai, M., Ono, T., & Nakamura, K. (2008). Up-regulation of hyaluronan synthase by palmitoyl oligopeptide in human dermal fibroblasts. Journal of Dermatological Science, 50(2), 123-130.

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