Matrixyl 3000 cream is formulated with a complex of skin-beneficial botanical extracts. Key components include soothing aloe vera juice, emollient shea butter, and light-textured jojoba oil, which synergistically provide profound and sustained hydration, effectively alleviating skin dryness and associated discomfort.
Our Kpeptide GMP facility has successfully passed on-site GMP inspections by multiple regulatory agencies, including the China Food and Drug Administration (CFDA), the U.S. Food and Drug Administration (USFDA), the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan, the Ministry of Food and Drug Safety (MFDS) of Korea, and the Hamburg Health Authority (BGV Hamburg) of Germany. Furthermore, our main products have obtained numerous internationally recognized certifications, such as the Certificate of Applicability (CEP) from the U.S. Food and Drug Administration (USFDA) and the EU GMP certificate.
Our products
Matrixyl 3000 Cream COA
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| Certificate of Analysis | ||
| Compound name | Matrixyl 3000 Cream | |
| Grade | Pharmaceutical grade | |
| CAS No. |
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| Quantity | 12g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090051 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.55% |
| Loss on drying | ≤1.0% | 0.47% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.87% |
| Single impurity | <0.8% | 0.67% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 463ppm |
| Storage |
Store in a sealed, dark, and dry place below 2-8°C |
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| Chemical Formula: | C39H75N7O10 | |
| Exact Mass: | 802 | |
| Molecular Weight: | 802 | |
| m/z: | 802 (100.0%), 803 (42.2%), 804 (8.7%), 803 (2.6%), 804 (2.1%), 804 (1.1%) | |
| Elemental Analysis: | C, 58.40; H, 9.43; N, 12.22; O, 19.95 | |
Solid-phase Synthesis Stage of Single Peptides for Matrixyl 3000
Resin Activation Stage
Select the Rink Amide MBHA resin as the solid-phase carrier, fully swell it in anhydrous dimethylformamide (DMF), then remove the Fmoc protecting group on the resin surface with 20% piperidine/DMF solution to expose the free amino sites for subsequent amino acid coupling.
Sequential Amino Acid Coupling Stage
Follow the preset peptide sequence order, add Fmoc-protected amino acids one by one, with HBTU/HOBt as the coupling activator. Each coupling reaction lasts 30-45 minutes at room temperature, and the ninhydrin detection method is used to confirm that the single-step coupling efficiency reaches over 99.5% before proceeding to the next amino acid grafting step.
N-terminal Palmitoylation Stage
After the full peptide backbone (GHK for tripeptide, GQPR for tetrapeptide) is completely assembled on the resin, palmitic acid is added to carry out the acylation modification reaction at the N-terminal free amino group, to introduce the lipophilic palmitoyl group that enhances skin penetration.
Side Chain Deprotection and Peptide Cleavage Stage
After the palmitoylation reaction is fully completed, the target peptide chain is cleaved from the solid resin using a trifluoroacetic acid (TFA) cleavage solution. At the same time, all side chain protecting groups of the amino acid residues are removed, and the crude single peptide product is precipitated and washed with ice-cold diethyl ether for subsequent purification.
Applications of Matrixyl 3000 as an Efficacy Calibrator in 3D Reconstructed Skin Models
System Baseline Calibration Application
It serves as a unified positive reference to calibrate the baseline response of different batches of 3D reconstructed skin models. By detecting its standard efficacy readouts including collagen synthesis promotion rate and IL-6 inhibition rate, it eliminates systematic deviations caused by differences in skin model culture batches, operators and testing equipment, ensuring the horizontal comparability of all subsequent test data.
Efficacy Sensitivity Threshold Calibration Application
It is used to lock the minimum detectable efficacy threshold of the 3D skin model system. The dose-effect curve of Matrixyl 3000 across a series of concentration gradients can accurately define the lowest active concentration that the model can stably identify, avoiding false negative results that miss low-activity anti-aging ingredients.
Anti-aging Efficacy Quantification Benchmark Application
It provides a fixed reference scale for quantifying the anti-aging performance of test ingredients.
Researchers can convert the absolute collagen promotion data of new test samples into relative efficacy values relative to Matrixyl 3000 cream, which makes the efficacy evaluation results no longer limited to qualitative descriptions and achieves standardized quantitative comparison.
Photoaging Intervention Effect Calibration Application
In UV-induced photoaging 3D skin models, it calibrates the model's response sensitivity to light damage repair interventions. It can accurately verify whether the test anti-photoaging ingredient can effectively reverse the UV-induced collagen degradation and barrier damage, and exclude false positive signals caused by model system errors.
Long-term Efficacy Stability Verification Application
Kpeptide In long-term repeated intervention experiments spanning over 2-4 weeks, its stable and non-cytotoxic properties make it an ideal reference to verify the long-term efficacy retention performance of test ingredients in the 3D skin model,
which is closer to the actual long-term use scenario of skincare products on human skin.
Application of Matrixyl 3000 for Calibrating Activity Detection Sensitivity Across Different Cell and 3D Skin Aging Models
Cross-Cell Line Sensitivity Calibration
Its well-documented dose-dependent collagen-promoting and anti-inflammatory effects can unify the detection sensitivity benchmarks of different dermal fibroblast cell lines, eliminating systematic deviations caused by differences in cell passage states and operator operations. It accurately locks the minimum detectable efficacy threshold for each cell-based anti-aging screening system.
3D Reconstructed Skin Model Sensitivity Validation
Kpeptide With its stable transdermal performance in full-thickness 3D skin equivalents, it calibrates the response sensitivity of different 3D skin aging models (natural aging, UV-induced photoaging, high-inflammation aging) to anti-aging interventions. It ensures that the efficacy data obtained from different 3D model batches are horizontally comparable.
Cross-Platform Data Unification Reference Matrixyl 3000 cream acts as a universal positive control to align the sensitivity parameters of different detection platforms in the same research workflow.
This avoids the common problem that the efficacy results of the same test anti-aging ingredient show large discrepancies across different detection methods.
False Signal Exclusion Function
Its clear dual-peptide mechanism and non-cytotoxic properties help distinguish real anti-aging efficacy signals from random experimental noise. It effectively reduces the false positive and false negative rates of the entire screening system, making the evaluation results of new anti-aging ingredients more reliable and reproducible.
Application of Matrixyl 3000 in Reducing False Positive and False Negative Rates of the Anti-aging Screening System
False Positive Rate Reduction Mechanism
Its well-defined dual-peptide mechanism and stable dose-effect curve provide a clear, non-ambiguous efficacy benchmark. It helps researchers distinguish random experimental noise, non-specific cellular stress responses and non-targeted interference signals from real anti-aging efficacy, effectively excluding misjudgments that mark inactive or low-activity samples as effective anti-aging candidates.
False Negative Rate Reduction Mechanism
By calibrating the minimum detectable sensitivity threshold of the entire screening system, it locks the lowest effective concentration that the system can stably identify. This avoids the missed detection of low-concentration but genuinely active anti-aging ingredients, which are often overlooked in uncalibrated screening workflows with overly strict efficacy cut-off values.
Cross-Batch Data Consistency Guarantee
As a unified quality control reference added to each batch of screening experiments, it eliminates systematic deviations caused by differences in cell passage states.
Kpeptide operator operations and experimental equipment performance across different batches. It ensures that the efficacy judgment criteria remain consistent for all test samples, further stabilizing the screening system and reducing the overall error rate.
Screening System Reliability Improvement
After calibration with Matrixyl 3000 cream, the overall error rate of the anti-aging ingredient screening system can be reduced to below 10%. This significantly improves the hit rate of discovering high-value anti-aging active substances, and greatly cuts down the unnecessary follow-up verification costs caused by misjudged samples.
Basic Transportation of Matrixyl 3000 Cream
Hazard Classification Attribute
It does not fall into any dangerous goods category defined by international transport regulations, with no flammable, explosive, corrosive, radioactive or highly toxic properties. It can be transported as ordinary non-special cosmetics, and no hazardous material transportation qualification or special dangerous goods declaration is required for the whole logistics process.
Temperature Adaptation Attribute
The finished cream product maintains excellent physical and chemical stability within the conventional temperature range of 5℃ to 35℃, and no full cold chain transportation is required. It only needs to avoid long-term exposure to extreme environments above 40℃ or below -5℃, which may cause emulsion matrix stratification, discoloration or partial activity loss of the peptide active ingredients.
Packaging and Shock Resistance Attribute
The product is usually sealed in airtight cosmetic-grade containers.
During transportation, only standard anti-extrusion, drop-proof buffer protection is required to prevent packaging breakage and liquid leakage. No extra high-intensity shockproof packaging is mandatory, and shading measures on the outer package can effectively avoid potential activity attenuation of the peptide components caused by long-term strong direct light.
Compatibility Attribute
It can be transported in the same warehouse with most ordinary daily chemical, non-food and non-dangerous goods. It only needs to avoid long-distance mixed transportation with strong oxidizing agents, strong corrosive chemicals and high-concentration organic solvents, which may cause potential erosion to the outer packaging and contaminate the product.
Frequently Asked Questions
Q: What makes Matrixyl 3000 a reliable positive control for anti-aging ingredient screening?
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A: It has a well-documented dual-peptide mechanism, with published clinical data showing a 44% reduction in deep wrinkle area after 56 days of use. Its stable, dose-dependent collagen-promoting effect creates a standardized benchmark that eliminates cross-batch experimental system errors.
Q: Does Matrixyl 3000 cause cytotoxicity or abnormal cell proliferation in long-term intervention experiments?
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A: No. It has an excellent safety profile with no reported cytotoxicity at working concentrations, and it will not trigger unregulated fibroblast over-proliferation, which avoids the common side effects of some strong collagen-stimulating ingredients.
Q: Can Matrixyl 3000 be used to verify the synergistic effect of compound anti-aging formulas
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A: Absolutely. Its dual-pathway mechanism can clearly distinguish whether a new tested ingredient produces additive, synergistic or antagonistic effects when combined with it, making it ideal for compound formulation development researc
Q: What temperature control conditions are required for long-term storage of research-grade Matrixyl 3000 cream?
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A: For long-term storage over 3 months, 2℃-8℃ under dark conditions is recommended to fully preserve the biological activity of the two active peptides, and it does not require strict -20℃ cryopreservation for routine use.
Q: How can I confirm that the Matrixyl 3000 creram I received is the high-purity genuine product as labeled?
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A: Each batch of products comes with a unique traceable batch number. You can enter the batch number through Kpeptide's official channels to directly retrieve the original test data from the corresponding third-party laboratory, avoiding receiving generic template reports, expired reports, or substandard raw materials.
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