Among the active components of marine organisms, sea cucumber peptide have shown unique value in the fields of skin care and body function regulation due to their small molecule permeability and targeted activity. Its core efficacy focuses on three dimensions: skin barrier repair, oxidative damage protection, and physical fatigue relief. It acts on the body through multiple pathways to achieve maintenance and regulation from the inside out. The following provides a detailed breakdown and explanation of its mechanism of action, efficacy characteristics, and practical evidence.
Our Products Description
Sea Cucumber Peptide COA
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| Certificate of Analysis | ||
| Compound name | Sea Cucumber Peptide | |
| Grade | Pharmaceutical grade | |
| CAS No. | 84625-50-3 | |
| Quantity | 30g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090063 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure | N/A | |
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.54% |
| Loss on drying | ≤1.0% | 0.42% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.52% |
| Total microbial count | ≤750cfu/g | 95 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage |
Store in a sealed, dark, and dry place 2-8°C |
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Skin barrier repair and soothing of sensitive damage
The repairing effect of sea cucumber peptide on the skin barrier relies on its high permeability of small molecule structure, breaking through the barrier of the epidermal stratum corneum and directly reaching the deep layers of the skin, achieving the reconstruction of the barrier from the root and sensitivity relief. The specific manifestations are as follows:
Steady state reconstruction of stratum corneum
The specific amino acid components it contains can promote the proliferation and differentiation of keratinocytes, upregulate the expression levels of lactoglobulin (LOR) and filaggrin (FLG).
Improve the loose state of damaged stratum corneum, fill the barrier gap, reduce the penetration of external stimuli, strengthen the skin's own water locking and protective ability, reverse the problems caused by barrier damage such as dryness and flaking, and achieve gradual recovery of barrier function.
Sensitive damage relief
Its active ingredients can efficiently inhibit the excessive release of various inflammatory mediators in the epidermis and dermis, and effectively antagonize the adverse skin stimulation induced by common allergic triggers including histamine. It visibly relieves a range of typical discomfort symptoms of sensitive and barrier-damaged skin, such as persistent flushing and redness, tight and dehydrated dryness, recurrent itching, as well as stinging and burning sensation caused by external irritation.
Meanwhile, it can gradually lower the skin nerve sensitivity to external environmental stimuli like dry air, temperature changes and cosmetic irritation. It is especially suitable for problematic skin conditions such as seasonal periodic sensitivity, post-sun skin damage and weakened fragile skin barriers.
By calming epidermal inflammation and replenishing lipid barrier nutrients at the same time, it perfectly achieves a dual protective effect of mild instant soothing and long-term barrier repairing.
Regulation of Skin Microecological Balance
It can gently regulate the proliferation and colonization of beneficial microorganisms on the skin surface, while effectively inhibiting the reproduction and invasion of harmful bacteria. It maintains the dynamic balance and stability of the skin microecological flora, reduces skin barrier damage and allergic sensitivity triggered by microbial imbalance. Furthermore, it provides a healthy and stable microenvironmental foundation for gradual skin barrier repair, and effectively prolongs the lasting maintenance of skin repairing effects.
The information in the above section comes from:
Chen Chunming, Mi Rui, Yu Shuang, etc Research progress on preparation methods and skincare related effects of sea cucamber peptides [J]. Food Industry Science and Technology, 2025, 46 (11): 434-445
Yuan Gao, Chunming Dong. Research Progress and Application Prospects of Sea Cucamber Peptides[J]. Francis Academic Press, 2025, 6(1): 117-129.
Free radical scavenging and cellular DNA protection
The antioxidant efficacy of sea cucumber peptide lies in their precise clearance of free radicals and effective blockade of lipid peroxidation, thereby achieving comprehensive protection of cells and DNA and avoiding functional decline caused by oxidative damage. This is reflected in three dimensions:
01.Specific free radical scavenging
Its active peptide segment can selectively scavenge DPPH free radicals and hydroxyl free radicals produced by the body's metabolism, among which the clearance of DPPH free radicals has a clear dose-dependent effect.
The IC50 values of some components can be as low as 0.1416 mg/mL, and after simulating gastrointestinal digestion in vitro, more than 70% of the clearance activity can still be retained, avoiding cellular oxidative damage caused by the accumulation of free radicals in the body.
02.Lipid peroxidation blockade
It can inhibit the initiation and progression of lipid peroxidation chain reaction, reduce the production of oxidative product malondialdehyde (MDA), protect the integrity of cell membrane.
Reduce the damage of lipid oxidation to cell structure and function, especially have a significant protective effect on lipid components on cell membrane, and delay the oxidative aging process of cells.
03.Cell and DNA protection
Its active components can penetrate into the interior of cells, reducing the oxidative attack of free radicals on DNA by chelating metal ions, clearing reactive oxygen species, etc., alleviating DNA damage caused by hydroxyl radicals.
Reducing the probability of DNA strand breakage, while protecting the activity of antioxidant enzyme systems in cells, enhancing the body's own antioxidant defense ability, and achieving dual protection between cells and genetic material.
The information in the above section comes from:
Chen Chunming, Mi Rui, Yu Shuang, et al. Research Progress on Preparation and Skin Care Related Effects of Sea Cucamber Peptides[J]. Science and Technology of Food Industry, 2025, 46(11): 434-445.
Fu Hongzheng, Li Meng, Yu Shuang Research on the Skin Barrier Repair Mechanism and Application of Sea Cucamber Peptide [J]. Journal of Peking University (Medical Edition), 2024, 56 (03): 589-596
Relieve physical fatigue and regulate energy metabolism
The soothing effect of sea cucumber peptide on physical fatigue lies in regulating the excretion of metabolic products and the storage of energy substances in the body, alleviating discomfort caused by the accumulation of fatigue factors, and improving endurance. It can be divided into three aspects:
Regulation of fatigue metabolites
It can accelerate the metabolism and decomposition of lactate in the body, promote the activity of lactate dehydrogenase, reduce the accumulation of lactate in muscle tissue, and alleviate fatigue symptoms such as muscle soreness and fatigue.
At the same time, it promotes the excretion of urea nitrogen, reduces its concentration in the blood, alleviates the metabolic burden on the kidneys, reduces fatigue caused by protein breakdown metabolism, and accelerates the recovery of fatigue in the body.
Energy reserve enhancement
It can effectively promote the synthesis and storage of hepatic glycogen, significantly elevate glycogen accumulation within liver tissue, deliver stable and sustained energy supply for physiological metabolism, and alleviate physical fatigue triggered by inadequate energy reserve and consumption overload. It is especially suitable for rapidly replenishing physical energy after high-intensity exercise and heavy physical exertion, effectively prolonging physical endurance, delaying the onset of fatigue, and markedly improving the body's post-exercise recovery efficiency.
Regulation of metabolic enzyme activity
It can upregulate the activity of energy metabolism related enzymes such as pyruvate kinase and malate dehydrogenase in skeletal muscle, promote efficient glycolysis and tricarboxylic acid cycle.
Optimize energy metabolism pathways, improve energy utilization efficiency, reduce fatigue at the root, and achieve rapid physical recovery and endurance improvement.
The information in the above section comes from:
Fan Mengqi, Yan Guangyu, Chen Wanhao, etc Preparation and functional study of antioxidant mediated anti fatigue sea cucamber peptides [J]. Chinese Journal of Food Science, 2024, 24 (10): 1-12
References
Olivera-Castillo M, et al. Antioxidant Activity of Sea Cucamber Protein Hydrolysates and Their Protective Effects on DNA Damage[J]. Journal of Marine Science and Engineering, 2024, 12(8): 1123-1135.
Anonymous Repair activity of sea cucamber oligopeptides on skin barrier damage [J]. VIP Journal, 2024, (05)：7202560386.
Li J, Wang H, Zhang Y. Sea Cucamber Peptides Alleviate Physical Fatigue by Regulating Energy Metabolism and Oxidative Stress[J]. Journal of Functional Foods, 2024, 118: 105892.
Zhao Qiancheng, Qi Yanxia, Li Ying, etc Research on the Biological Activity and Skincare Efficacy of Sea Cucamber Peptides [J]. Journal of Dalian Ocean University, 2025, 40 (02): 312-318
FAQ
It is recommended to conduct a local skin test before using sensitive skin for the first time, avoiding damaged or inflamed areas; Prioritize selecting sea cucamber protein peptide products with high purity and molecular weight ≤ 2000Da to reduce skin irritation; Paired with a gentle and non irritating skincare routine, avoiding the use of powerful cleansing and exfoliating products, it is more conducive to repairing the skin barrier and soothing sensitivity.
Daily supplementation recommendations should follow the recommended daily dosage, taken 1-2 times. Exercise enthusiasts can supplement within 30 minutes after exercise, which is more conducive to lactate metabolism and liver glycogen reserve, helping to quickly relieve fatigue after exercise; Non exercise individuals can take it after meals to reduce gastrointestinal irritation, improve absorption efficiency, and avoid excessive supplementation that increases metabolic burden.
Compared to traditional antioxidant components, the small molecular structure of sea cucamber protein peptides is more easily permeable to the interior of cells. They can not only directly scavenge DPPH and hydroxyl radicals, but also inhibit lipid peroxidation chain reactions. At the same time, they provide more targeted protection for cells and DNA, and can still retain high activity after gastrointestinal digestion, making them more widely applicable in various scenarios.
In general, continuous use of skincare products or supplements containing sea cacumber protein peptides for 2-4 weeks can result in significant improvement, gradually relieving symptoms of sensitivity, redness, dryness, and itching, and increasing the tightness of the stratum corneum. The specific cycle may vary slightly depending on individual skin conditions, and those with severe barrier damage may need to persist in use for a longer period of time.
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