Transdermal Peptide

As a well-validated, biologically inspired transdermal enhancer, Transdermal Peptide serves as a core functional component in the R&D of macromolecule transdermal delivery systems, supporting multiple key research directions for non-invasive macromolecule administration

‌Functional Validation of Macromolecule Delivery Carriers‌

As a classic amphipathic short peptide carrier, it mediates high-molecular-weight therapeutics including insulin, human growth hormone and other protein drugs to penetrate the dense "brick-and-mortar" structure of the stratum corneum. 

It significantly elevates the transdermal permeation efficiency of these macromolecules into systemic circulation, enabling researchers to systematically verify the feasibility of non-invasive transdermal delivery for biomacromolecules.

‌Surface Modification of Nano-Drug Delivery Systems‌

It can be covalently or non-covalently modified on the surface of nanocarriers such as liposomes, polymeric nanoparticles and transferosomes. This modification enhances the interaction between nanocarriers and skin barrier lipids as well as keratinocyte membrane proteins.

BLOOM effectively improving the skin penetration capacity of nano-systems and the local enrichment of loaded macromolecules in target dermal sites, which supports the development of targeted transdermal delivery strategies for skin diseases like cutaneous melanoma and psoriasis.

‌Transdermal Delivery Exploration for Nucleic Acid Macromolecules‌

By specifically binding to the β-subunit of Na⁺/K⁺-ATPase on the surface of epidermal cells, it reversibly loosens the tight junctions in the stratum corneum and forms temporary, size-permeable microchannels.

This mechanism allows highly hydrophilic, negatively charged nucleic acid macromolecules such as siRNA, mRNA and antisense oligonucleotides to efficiently cross the intact skin barrier, breaking through the long-standing bottleneck of nucleic acid transdermal delivery and expanding the R&D boundary of nucleic acid-based topical and systemic delivery systems.

Formulation Development Support for Macromolecule Transdermal Preparations‌

BLOOM product is widely applied in the formulation optimization of various transdermal preparations including patches, hydrogels, creams and microneedle formulations. It helps clarify the regulatory rules of macromolecule transport across the skin barrier, providing solid theoretical basis for the rational design of next-generation high-efficiency macromolecule transdermal delivery systems.

‌Safety and Biocompatibility Evaluation of Delivery Systems

Leveraging its unique reversible action feature, Transdermal Peptide supports the verification of the full recovery capacity of the skin barrier after macromolecule transdermal permeation. It is also used to evaluate the long-term skin irritation, local toxicity and systemic biocompatibility of the whole delivery system, providing critical preclinical safety data to accelerate the subsequent clinical translation of macromolecule transdermal delivery platforms.

It also avoids the first-pass effect of the liver, providing a critical technical support for the development of innovative long-term administration systems for chronic diseases such as diabetes.

‌Fundamental Mechanism Research of Transdermal Delivery‌

As a standardized model tool molecule, it assists researchers in systematically analyzing core processes during macromolecule transdermal transport, including lipid pathway reconstruction, intercellular diffusion regulation and intracellular trafficking pathways.

helps clarify the regulatory rules of macromolecule transport across the skin barrier, providing solid theoretical basis for the rational design of next-generation high-efficiency macromolecule transdermal delivery systems.

‌Safety and Biocompatibility Evaluation of Delivery Systems‌
Leveraging its unique reversible action feature, it supports the verification of the full recovery capacity of the skin barrier after macromolecule transdermal permeation. It is also used to evaluate the long-term skin irritation, local toxicity and systemic biocompatibility of the whole delivery system, providing critical preclinical safety data to accelerate the subsequent clinical translation of macromolecule transdermal delivery platforms.

Difference in the Reversibility of Skin Barrier Function

Transdermal Peptide: Works by specifically binding to the β-subunit of Na⁺/K⁺-ATPase in the epidermis. It reversibly relaxes the tight connections of the stratum corneum without disrupting the inherent structure of the skin's lipid bilayer. After the penetration enhancement process, the skin barrier can completely and autonomously recover to its normal state without any risk of permanent damage.Traditional Chemical Penetration Enhancers (Azone, DMSO, Fatty Acids, etc.):Rely on physicochemical actions to directly disrupt the lipid arrangement of the stratum corneum, damaging the dense layered structure of the skin barrier. Some highly active ingredients can cause lipid loss from the stratum corneum, making it difficult for the barrier to fully repair itself after damage.
Conventional Lipopeptide-Based Biological Penetration Enhancers: Achieve penetration by loosening the lipid structure of the stratum corneum.

The degree of disturbance to lipid arrangement is greater than that of Transdermal Peptide. In some high-concentration application scenarios, it can cause excessive loss of endogenous lipids in the skin.

Differences in Skin Irritation and Sensitization

Transdermal Peptides: These are short, biologically derived peptides with well-defined sequences and no immunogenicity.Traditional Chemical Penetration Enhancers:Most of these ingredients can cause varying degrees of skin irritation at effective penetration concentrations. Long-term, repeated use can easily lead to adverse reactions such as dry skin, peeling, and inflammation. Some organic solvent-based penetration enhancers also have significant mucosal irritation.Common Cell-Penetrating Peptides (e.g., TAT): These lack skin-targeting specificity and tend to accumulate non-specifically within epidermal cells. High concentrations may induce cytotoxicity, and some cationic peptides also pose a potential risk of sensitization.

‌Core Temperature Benchmark‌: The product requires long-term sealed storage at -20 °C away from light. The whole transportation process must refer to this standard to prevent conformational changes of the active Transdermal Peptide and disulfide bond breakage that will cause irreversible activity loss. ‌Temperature Control for Short-distance Domestic Research Orders‌: For small-specification domestic short-distance orders, the cold chain packaging composed of ice packs and insulated foam boxes can maintain a stable low temperature of 0-4 °C for more than 48 hours.

fully covering the conventional express delivery timeliness and meeting basic temperature control requirements.

‌Temperature Control for Long-distance/Cross-border Transportation‌: For inter-regional or cross-border long-haul shipments, BLOOM dry ice combined with a high-sealing insulated box is adopted, which can sustain a low temperature of -20 °C or below for 72-96 hours throughout the journey, avoiding peptide moisture absorption and activity degradation caused by temperature rise during prolonged transportation.

‌Temperature Fluctuation Risk Avoidance‌: Prolonged exposure to room temperature above 25 °C outside the low-temperature environment is strictly prohibited during the whole transportation process. Repeated freeze-thaw temperature fluctuations are also forbidden, as these conditions will directly disrupt the spatial conformation of the peptide chain and drastically reduce the biological activity of the product.
‌Temperature Control Verification Service‌: For high-value bulk orders, a temperature data logger can be optionally equipped to record real-time temperature data throughout the transportation process.