Oligopeptide-34 Injection

Oligopeptide-34 Injection
Details:
1.General Specification(in stock)
(1)API(Pure powder)
(2)Injection
2.Customization:
We will negotiate individually, OEM/ODM, No brand, for secience researching only.
Internal Code: KP-1-44/001
Oligopeptide-34 CAS 2227218-62-2
HS code: N/A
Molecular formula: N/A
Molecular weight: 0
EINECS number: N/A
MDL No.: N/A
Manufacturer: BLOOM TECH Wuxi Factory
Analysis: HPLC, LC-MS, HNMR
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Technology support: R&D Dept.-4
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Description
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Oligopeptide-34 injection peptide solution, specifically developed for membrane therapy formulations. This signal peptide targets hyperpigmentation, brightens the skin, has anti-inflammatory effects, and stimulates the production of collagen. Kpeptide company manufactures according to GMP standards and can provide full batch COA documents. The minimum order quantity for Kpeptide is 1 box, and bulk orders can also be provided for cosmetic laboratories.

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Oligopeptide-34 | Kpeptide

Oligopeptide-34 powder | Kpeptide

Oligopeptide-34 injection | Kpeptide

Oligopeptide-34 price list | Kpeptide

Oligopeptide-34 price list | Kpeptide

Method of Analysis | Kpeptide

Oligopeptide-34 COA

Kpeptide
Certificate of Analysis
Compound name Oligopeptide-34
Grade Pharmaceutical grade
CAS No. 2227218-62-2
Quantity 70g
Packaging standard PE bag+Al foil bag
Manufacturer Shaanxi BLOOM TECH Co., Ltd
Lot No. 202601090058
MFG Jan 9th 2026
EXP Jan 8th 2029
Structure N/A
Item Enterprise standard Analysis result
Appearance White or almost white powder Conformed
Water content ≤5.0% 0.47%
Loss on drying ≤1.0% 0.35%
Heavy Metals Pb≤0.5ppm N.D.
As≤0.5ppm N.D.
Hg≤0.5ppm N.D.
Cd≤0.5ppm N.D.
Purity (HPLC) ≥99.0% 99.93%
Single impurity <0.8% 0.31%
Total microbial count ≤750cfu/g 78
E. Coli ≤2MPN/g N.D.
Salmonella N.D. N.D.
Ethanol (by GC) ≤5000ppm 545ppm
Storage Store in a sealed, dark, and dry place below 2-8°C

Kpeptide

Application in melanin regulation


Kpeptide oligopeptide-34 injection is a highly active synthetic signal peptide, specifically developed for medical aesthetic treatments and high-end brightening and repairing formulas. Its core function is to regulate the generation, transport, and deposition metabolism of skin melanin throughout the entire process.

Repair skin micro inflammation and improve post inflammatory pigmentation (PIH) from the root
 

In clinical practice, post inflammatory hyperpigmentation (PIH) is the most common, difficult to repair, and frequently complained about by customers. After medical beauty treatments such as laser skin rejuvenation, fruit acid skin rejuvenation, acne repair, and sunburn repair, there may be a subtle inflammatory state in the skin that is not visible to the naked eye, which continuously activates melanocytes, leading to postoperative blackening, stubborn blackening of acne scars, and repeated darkening. This is also an industry pain point that traditional whitening ingredients cannot solve.

K-peptide oligopeptide-34 (CG-TGP2) has excellent anti-inflammatory and soothing properties, which can effectively reduce the concentration of pro-inflammatory cytokines in skin tissue, alleviate hidden skin micro inflammation, and block the vicious cycle of "inflammatory stimulation → melanocyte activation → excessive melanin production". It can quickly repair damaged skin after medical beauty treatment, relieve redness and sensitivity, and prevent secondary pigmentation caused by inflammation from the root, greatly reducing the risk of postoperative blackening in medical beauty projects.

oligopeptide-34 skin | Kpeptide

Improving customer experience and repurchase rate, and perfectly adapting to high-end formulas for mesodermal repair and postoperative repair. 

Adapt to various pigment issues, covering the needs of brightening and repairing in all scenarios

 

oligopeptide-34 skincare | Kpeptide

Relying on the compound effects of multi-channel anti blackening, anti-inflammatory and repair, K-peptide oligopeptide-34 (CG-TGP2) can effectively improve the majority of acquired skin pigmentation problems on the market, adapt to the diversified formula needs of medical beauty clinics and skincare factories, and cover scenarios far beyond traditional single whitening ingredients:
-Sun induced dark spots and darkening: Resist UV induced activation of melanocytes, improve skin darkening and local pigmentation accumulation after sun exposure;
-Systemic uneven skin tone, yellowish and dull complexion: evenly metabolize accumulated pigments on the epidermis, improve facial mottled, yellowish skin tone, poor transparency and other problems;
-Assistance in improving superficial melasma: Through the triple mechanism of inhibiting blackening, anti-inflammatory, and repairing, it assists in fading superficial melasma and inhibiting the deepening and expansion of pigmentation;

B-end commercial core advantages
 

Compared to traditional ingredients with severe homogenization such as vitamin C and arbutin, K-peptide oligopeptide-34 (CG-TGP2) truly solves the pain points of terminal sales: traditional ingredients have single efficacy, are prone to oxidative failure, have poor postoperative anti blackening improvement, and have average customer feedback, making it difficult to make differentiation. K-peptide oligopeptide-34 integrates anti blackening, anti blackening, anti-inflammatory, repairing, anti-aging and collagen promoting functions. Its formula has strong stability, extremely low irritation, and is suitable for mesodermal injection systems. It can help brands and medical beauty institutions create high-end differentiated spot lightening and brightening projects, increase product premiums, reduce customer complaints, and improve reputation and repurchase. It is an upgraded core material in the current pigment management track.

oligopeptide-34 uses | Kpeptide

What is Oligopeptide-34 and How It Works

Oligopeptide-34 injection acts on multiple steps of melanin production: 

 

1. Down-regulates tyrosinase, TRP-1, TRP-2 and MITF to reduce melanin synthesis.

 

2. Blocks melanosome assembly and transfer from melanocytes to keratinocytes.

 

3. Accelerates breakdown of MSH, the key trigger for tyrosinase overproduction.

 

4. Reduces TH1 pro-inflammatory cytokines, easing post-inflammatory hyperpigmentation (PIH).

 

5. Stimulates fibroblast activity to boost collagen, elastin and fibronectin in dermis, improving skin firmness.

 

Vitamin C vs Arbutin vs Oligopeptide-34 (CG-TGP2) Comparison Table

 

Kpeptide Professional Comparison: Traditional Brightening Ingredients VS Advanced Mesotherapy Peptide

 

Most conventional skin-brightening raw materials only work on a single melanin inhibition pathway with obvious limitations in stability, irritation and comprehensive skincare effects. While Kpeptide Oligopeptide-34 (CG-TGP2) acts on multiple skin layers and solves the core pain points of traditional ingredients, becoming a high-value formula material for premium mesotherapy and aesthetic clinic projects.

Comparison Dimension
Vitamin C (L-Ascorbic Acid)
Arbutin
Kpeptide Oligopeptide-34 (CG-TGP2)

Mechanism of Action

Only inhibits tyrosinase activity and reduces existing melanin through oxidation resistance; works only on a single melanin synthesis pathway with no repair or anti-aging effects.

Competitively inhibits tyrosinase to block melanin formation; only targets the initial stage of melanin production, without interfering with melanin transfer or skin inflammation.

Multi-pathway comprehensive action: down-regulates tyrosinase, TRP-1, TRP-2 and MITF; blocks melanosome transfer; reduces inflammatory factors to improve PIH; stimulates dermal collagen and elastin regeneration.

Core Efficacy

Basic antioxidant and superficial brightening; only effective for mild sun spots and dull skin.

Fades superficial pigment and improves uneven skin tone; single functional positioning.

Three-in-one efficacy: deep pigment removal, anti-inflammation repair, and collagen boosting. Effectively improves sun spots, melasma and post-inflammatory hyperpigmentation.

Skin Irritation

High irritation in high concentration; acidic property easily causes redness, stinging and skin sensitivity.

Low mild irritation, but high dosage may trigger skin intolerance; not friendly for sensitive skin after medical beauty treatment.

Pure synthetic signal peptide with ultra-low irritation. Safe for sensitive skin and skin after laser, peeling and other aesthetic treatments.

Formula Stability

Extremely unstable, easily oxidized and yellowed by light, oxygen and pH change; high formula failure rate and short shelf life.

Moderate stability, easy to decompose in alkaline environment; limited application in complex formulas.

Excellent water-soluble stability, not easy to oxidize and deteriorate. Perfectly compatible with non-crosslinked HA and other functional peptides for mesotherapy cocktails.

Mesotherapy Injection Suitability

Poor applicability. Acidic ingredients easily cause subcutaneous irritation and invalid oxidation after injection.

General applicability. Mainly used for topical skincare, with great limitations in sterile injection formulas.

Excellent applicability. Sterile professional solution specially developed for mesotherapy injection formulas, safe and effective for dermal delivery.

Product & Business Defects

Single efficacy, unstable quality, high after-sales complaint rate of skin irritation; unable to support high-end aesthetic project positioning.

Weak improvement on inflammatory pigmentation, no anti-aging effect; low formula added value and serious market homogenization.

Slightly higher unit cost than traditional ingredients, but with comprehensive efficacy and low after-sales risk; brings higher profit margin and project competitiveness.

Core Sales Advantage for Buyers

Low cost and high market awareness, but unable to form differentiated competitive advantages.

Basic popular brightening material, only suitable for low-end daily skincare products.

Break market homogenization. Helps cosmetic labs and aesthetic clinics launch exclusive multi-effect brightening & anti-aging projects, increase customer repurchase rate and project premium, and greatly reduce pigment rebound complaints.

Summary

Traditional brightening ingredients (Vitamin C, Arbutin) can only achieve single superficial brightening with many limitations in stability, safety and comprehensive efficacy. As an upgraded new-generation peptide raw material, Kpeptide Oligopeptide-34 (CG-TGP2) realizes multi-dimensional improvement of pigmentation repair, anti-inflammatory soothing and skin anti-aging. It is the preferred high-value raw material for premium mesotherapy and medical aesthetic skincare formulas.

 

Disclaimer: This product is a cosmetic raw material for mesotherapy formula compounding only, not a pharmaceutical drug. All injection operations must be performed by licensed professional medical practitioners.

Frequently Asked Questions

Q1: Is Oligopeptide-34 injection a drug?

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A: No. Oligopeptide-34 is a cosmetic raw material / research peptide. Kpepetide sterile solution is designed for cosmetic mesotherapy compounding by licensed practitioners. It is not approved as an injectable medicine for disease treatment. All end users must comply with local cosmetic and medical regulations.

Q2: Can Oligopeptide-34 mix with hyaluronic acid or other peptides?

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A: Yes. It has good compatibility with low molecular weight HA, oligopeptide-1, oligopeptide-2 and other anti-aging peptides. We recommend small pre-test for pH and stability before large batch mixing.

Q3: What concentration is commonly used in mesotherapy injection?

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A: Typical working concentration ranges from 10ppm to 50ppm in final cocktail. Final dosage and treatment protocol should be decided by dermatologist according to skin condition.

Q4: What documents can you provide for customs and clinic audit?

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A: Each shipment comes with COA, HPLC chromatogram, MSDS, heavy metal and microbial test certificates. We can support proforma invoice for bulk orders.

Q5: What is your MOQ and lead time?

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A: MOQ for sterile Oligopeptide-34 injection solution starts at 10 vials. Bulk manufacturing lead time is 7–14 working days after deposit. Custom concentration and private labeling are available.

References

[1] The International Dermal Institute. Oligopeptide-34: Advances in Skin Brightening[EB/OL]. 2019. Verified the dual mechanism of Oligopeptide-34 inhibiting melanin synthesis, reducing tyrosinase activity and blocking melanosome transfer, and confirmed its stable brightening effect on human melanocyte models.

[2] International Journal of Molecular Sciences. Melanocyte Activation Mechanisms and Rational Therapeutic Treatments of Solar Lentigos[J]. 2019. Elaborated the MITF/tyrosinase/TRP-1/TRP-2 melanogenic signaling pathway, providing core theoretical basis for Oligopeptide-34 multi-pathway melanin regulation.

[3] TGP-2 PEPTÍDEO® Professional Technical White Paper. Evidence Pharmacy Research Laboratory, 2020. Systematically verified that CG-TGP2 (Oligopeptide-34) down-regulates MITF gene expression, inhibits melanosome assembly and transfer, and improves inflammatory post-pigmentation (PIH).

[4] Mobelbio Cosmetic Peptide Research Report. Core Efficacy Verification of Oligopeptide-34, 2026. In vitro experiments confirmed that Oligopeptide-34 can reduce tyrosinase activity by about 65%, with significantly better pigment inhibition performance than Vitamin C and Arbutin.

[5] Cosmetic Ingredients Guide. Oligopeptide-34 Ingredient Mechanism Database[DB/OL]. 2026. Recorded the standard sequence of Oligopeptide-34 and its triple efficacy mechanism of anti-melanogenesis, anti-inflammatory and melanin metabolism promotion.

 

Safety & Disclaimer

For cosmetic formulation and research use only. Not for direct sale to end consumers as standalone injection.

Injection must be performed by licensed medical professionals.

Avoid use on broken skin, active infection, allergy history to peptides.

Storage, reconstitution and aseptic operation directly affect stability and safety.

Statements on this page have not been evaluated by regulators. This product is not intended to diagnose, treat, cure any disease.

 

 

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