Fertirelin belongs to the peptide hormone drug class, with a molecular formula of C55H76N16O12, a molecular weight of 1153.313, and a white to off white solid appearance. Its chemical structure has been optimized through artificial synthesis, retaining the core sequence of natural GnRH (such as His Trp Ser Tyr Gly Leu Arg Pro), but by replacing some amino acids (such as replacing the first amino acid with {Glp}) and adding an ethylamide group, the half-life of the drug in vivo has been prolonged, enhancing its binding ability to pituitary GnRH receptors. This structural modification enables it to continuously stimulate the secretion of LH and FSH in the anterior pituitary gland, thereby inhibiting the release of GnRH from the hypothalamus through a negative feedback mechanism, ultimately achieving bidirectional regulation of hormone levels.
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Fertirelin COA
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| Certificate of Analysis | ||
| Compound name | Fertirelin | |
| Grade | Pharmaceutical grade | |
| CAS No. | 79561-22-1 | |
| Quantity | 73g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202512090051 | |
| MFG | Dec 9th 2025 | |
| EXP | Dec 8th 2028 | |
| Structure |  |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.52% |
| Loss on drying | ≤1.0% | 0.41% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.37% |
| Total microbial count | ≤750cfu/g | 85 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 400ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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| Chemical Formula: | C55H76N16O12 |
| Exact Mass: | 1153 |
| Molecular Weight: | 1153 |
| m/z: | 1153 (100.0%), 1154 (59.5%), 1155 (17.4%), 1154 (5.9%), 1155 (3.5%), 1156 (2.5%), 1155 (2.5%), 1156 (1.5%), 1156 (1.0%) |
| Elemental Analysis: | C, 57.28; H, 6.64; N, 19.43; O, 16.65 |
Fertirelin is an artificially synthesized gonadotropin-releasing hormone (GnRH) analogue. Its chemical structure is unique, and by deeply simulating the core sequence of natural GnRH and carefully optimizing specific amino acids, it achieves efficient binding and persistent stimulation of pituitary GnRH receptors. This unique chemical property enables precise regulation within living organisms. It is like a delicate key, cleverly opening the regulatory door of the hypothalamic pituitary gonadal axis. By affecting the secretion of gonadotropins (LH and FSH), it indirectly regulates the hormone secretion of the ovaries or testes, bringing positive and far-reaching effects on the reproductive health and efficiency of animals.
The application in the field of animal medicine mainly benefits from its precise regulation ability on the reproductive cycle. This ability stems from its unique chemical structure and biological properties as a gonadotropin-releasing hormone (GnRH) analogue. It can flexibly simulate or inhibit the action of natural GnRH, like a skilled conductor, accurately commanding various "instruments" of the animal reproductive system, achieving precise regulation of the animal reproductive system. Through this regulation, key goals such as ovulation synchronization, estrus cycle recovery, and improved reproductive efficiency have been achieved, providing solid and powerful support for efficient production in animal husbandry.
Treatment of follicular cysts in bulls
Application scenarios
Ovarian cysts in bulls are a common and challenging reproductive disorder in animal husbandry. In the normal reproductive physiology of bulls, follicles will develop and mature step by step, ovulate smoothly, and then enter a new estrus cycle, repeating the cycle to maintain the reproductive ability of bulls. However, when follicular cysts appear, this normal physiological process is mercilessly disrupted. Follicles will continue to exist but cannot ovulate normally, like an out of control train deviating from the established track. This directly leads to the disruption of the estrus cycle of bulls, and even causes long-term infertility. For farmers, this is undoubtedly a disaster. Bulls cannot reproduce normally, which not only seriously affects their own reproductive performance, causing them to lose their value as bincubation mothers, but also brings huge economic losses to farmers. From feed costs, incubation management costs to expected economic benefits, every aspect is affected by the infertility of bulls.
Traditional treatment methods mainly rely on hormone injections, but this approach has many drawbacks. On the one hand, there are significant differences in the response of different bulls to hormones, just like how different people have different tolerance to drugs. This makes the treatment effect extremely unstable, and some bulls may not be able to effectively restore ovulation and estrus cycles, forcing farmers to face the dilemma of treatment failure. On the other hand, the cost of hormone therapy is relatively high, and for large-scale farms, long-term use of hormone therapy will bring significant economic pressure. Every hormone injection means an increase in cost, and the uncertainty of treatment effectiveness puts farmers in a dilemma.
clinical value
A large amount of research data fully demonstrates the excellent effect of Furirelin in the treatment of bovine follicular cysts. Related studies have shown that after a single injection of fertirelin, the ovulation rate of bulls can reach over 90%. This means that the vast majority of treated bulls are able to successfully restore ovulation function and return to a normal reproductive track. At the same time, the recovery time of bulls' estrus cycle has been significantly reduced to 7-10 days, which greatly shortens the waiting time for bulls to mate compared to traditional treatment methods. Under traditional treatment, bulls may take several weeks or even months to return to their estrus cycle, but the application of Furirelin makes this process efficient and fast, improving reproductive efficiency.
In addition, the pregnancy rate of incubation has also increased to 85%, effectively increasing the chances of pregnancy for bulls and improving the calf output rate of the incubation farm. Based on these significant therapeutic effects, Futirelin has become a first-line treatment for bovine follicular cysts and has been widely used worldwide. According to statistics, this drug saves billions of dollars in losses for the global livestock industry every year, which is of great significance for ensuring the stable development of the livestock industry and improving the economic benefits of incubation. It is like a magical doctor, bringing hope for the recovery of sick bulls and recovering economic losses for farmers.
Ovulation synchronization and artificial insemination
Application scenarios
In the large-scale incubation of bulls or beef cattle, ovulation synchronization is the core link to improve the efficiency of artificial insemination. The traditional ovulation synchronization method requires multiple injections of hormones, and the operation process is extremely complex. Aquaculture personnel need to accurately grasp the timing and dosage of each injection, just like operating on precision instruments, a slight mistake may affect the treatment effect. Moreover, multiple injections of hormones can cause strong stress reactions in bulls, leading to symptoms such as restlessness and decreased appetite.
These symptoms not only affect the health and productivity of bulls, but may also further impact the effectiveness of ovulation synchronization. In addition, traditional methods are difficult to accurately control the ovulation time of bulls, making it difficult to grasp the timing of artificial insemination. Just like shooting in the dark, it is easy to miss matches, which reduces the success rate of artificial insemination. This is undoubtedly a huge challenge for large-scale incubation farms, as every missed allocation means a loss of economic benefits.
Clinical value
In practical application on a 10000 head dairy farm in Australia, astonishing results have been demonstrated. After synchronous ovulation treatment with Fu Ti Rui Lin, the success rate of artificial insemination increased significantly from 65% to 82%. This means that more bulls can successfully conceive after one artificial insemination, reducing the number and cost of repeated insemination. Repeated insemination not only increases the cost of incubation, but also causes certain harm to the body of bulls. At the same time, the birth rate of calves has increased by 15%, significantly increasing the number of calves in the farm and providing sufficient cattle sources for the subsequent development of the farm.
In addition, due to the increased conception rate of bulls, the milk production also increases accordingly, with an annual increase of about 1200 tons of milk. This not only brings considerable economic benefits to the incubation farm, but also enhances its market competitiveness. In fierce market competition, an increase in production means being able to meet more market demand and win more customers. The application of Furirelin provides an efficient and convenient solution for ovulation synchronization and artificial insemination in large-scale dairy farms, promoting the development of animal husbandry towards scale and intensification. It is like a key that opens the door to efficient large-scale farming production.
Optimization of incubation performance of livestock
Application scenarios
The reproductive performance of incubation bulls or bulls plays a decisive role in the quality of offspring in the entire incubation farm. High quality incubation animals can inherit excellent genes, enabling their offspring to have better growth performance, reproductive performance, and disease resistance. However, traditional methods mainly rely on natural estrus to arrange incubation of livestock, but natural estrus is influenced by various factors such as season and environment, and has significant seasonal fluctuations.
During the non estrus season, the reproductive activities of incubation animals are restricted, making it difficult to meet the market's demand for high-quality incubation animals and offspring. Moreover, the natural estrus cycle is not fixed, making it difficult to make precise reproductive planning arrangements. Farmers are like sailing in the vast ocean, without clear direction, unable to arrange the incubation time of their livestock reasonably, which affects the production efficiency and economic benefits of the farm.
Clinical value
The actual application data of a certain livestock company in the United States fully proves the significant effect in optimizing the reproductive performance of incubation livestock. After use, the number of offspring produced by incubation cattle increased by 40%, which means that the farm can expand its incubation scale in a shorter period of time to meet the market's demand for high-quality incubation livestock and offspring. In today's increasingly competitive market, the expansion of aquaculture scale means being able to occupy more market share and obtain more economic benefits. At the same time, the proportion of high-quality livestock has increased by 25%.
These high-quality livestock have better genetic and production performance, which can bring higher economic benefits to the incubation farm. According to statistics, the farm has increased its annual income by over 5 million US dollars after using Flutilin, fully demonstrating the important role of Flutilin in improving the production efficiency and economic benefits of animal husbandry. The application of Futirelin provides a scientific and effective method for incubation and management of livestock, which helps to promote the development of animal husbandry towards high quality and high efficiency. Fertirelin is like a magical wizard, bringing a qualitative leap to the reproductive performance of livestock and injecting new vitality into the development of animal husbandry.
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