Carnosine 6mg/2ml injection is an injectable preparation featuring natural carnosine as its core active ingredient. Each 2 mL dose contains 6 mg of high-purity carnosine. Formulated with precise dosage ratios and boasting extremely high bioavailability, it is a functional polypeptide preparation widely adopted in exercise physiology and adjuvant clinical conditioning. As an endogenous dipeptide naturally synthesized in mammals, carnosine accumulates abundantly in high-energy metabolic tissues including skeletal muscle and cardiac muscle. Administered intravenously or intramuscularly, this injectable formulation bypasses metabolic losses in the digestive tract and directly enters the bloodstream to target the exercise metabolic system. For exercise physiology applications, it primarily mitigates lactic acid accumulation and acid-base imbalance induced by high-intensity workouts, delays the onset of exercise fatigue, and enhances physical endurance as well as post-exercise recovery efficiency. It also delivers auxiliary benefits including antioxidation, anti-inflammation, and protection of mitochondrial function in muscle cells.
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Carnosine COA
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| Certificate of Analysis | ||
| Compound name | Carnosine | |
| Grade | Pharmaceutical grade | |
| CAS No. | 305-84-0 | |
| Quantity | 41g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.22% |
| Loss on drying | ≤1.0% | 0.57% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.46% |
| Total microbial count | ≤750cfu/g | 550 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 610ppm |
| Storage | Store in a sealed, dark, and dry place below -20°C | |
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Mechanism of Action as a Potent pH Buffer (Core for Exercise Physiology)
Unique Molecular Structure Lays the Foundation for pH Buffering Capacity
The core active constituent of carnosine 6mg/2ml injection is carnosine, whose distinctive molecular structure underpins its powerful pH-buffering performance. Synthesized via peptide bond condensation between β-alanine and L-histidine, carnosine carries imidazole groups attached to histidine residues. These groups exhibit typical amphiprotic dissociation characteristics, enabling reversible proton binding and release under physiological acid-base conditions-this constitutes its key advantage over ordinary acid-base buffers. The normal physiological pH range of the human body stands at 7.35–7.45. During strenuous exercise, intensified anaerobic metabolism in skeletal muscle generates massive amounts of lactic acid and hydrogen ions, rapidly lowering intracellular pH in muscle cells and triggering acidosis, muscular soreness and weakness, and sharp declines in athletic performance.
With a pKa value of approximately 6.83, the imidazole group of carnosine perfectly covers the pH fluctuation range within human muscle cells during high-intensity exertion. Compared with endogenous buffer systems such as bicarbonates and phosphates in the body, its buffering threshold aligns more closely with the pathophysiological metabolic state of exercise, allowing targeted adaptation to acidic shifts during physical activity and efficient neutralization of pH deviations. Upon entering the human body, the high-purity carnosine from this injection rapidly accumulates in skeletal muscle tissue, compensating for insufficient endogenous carnosine synthesis and reinforcing the body's specialized acid-base buffering system for physical exertion.
Dynamic Neutralization of Hydrogen Ions Halts the Progression of Exercise-Induced Acidosis
During high-intensity endurance training or explosive workouts, oxygen supply fails to meet the demands of aerobic metabolism in skeletal muscle, shifting metabolic pathways toward anaerobic glycolysis. Incomplete glucose metabolism continuously produces abundant lactic acid, whose dissociated hydrogen ions build up in muscle cells and interstitial fluid and acidify the intramuscular microenvironment. Excessive hydrogen ion buildup suppresses the activity of key glycolytic enzymes and hinders the binding of actin and myosin, directly reducing muscle contractile force and athletic endurance. It also triggers severe post-workout muscle soreness and prolongs recovery periods.
After Carnosine injection takes effect, carnosine molecules concentrated in skeletal muscle initiate a dynamic proton buffering mechanism.When intracellular pH drops and hydrogen ion concentrations rise, imidazole groups rapidly bind free hydrogen ions, converting soluble acidic substances into stable bound complexes to swiftly reduce systemic hydrogen ion levels and arrest continuous pH decline. Once physical activity ceases and metabolic rates slow down, acidic metabolites are gradually metabolized and eliminated, and bound carnosine reversibly releases hydrogen ions to maintain stable systemic acid-base balance and prevent extreme pH swings. This dynamic, reversible buffering mechanism operates throughout the entire exercise session, fundamentally alleviating the inhibitory effects of exercise-induced acidosis on muscle function.
Optimization of Exercise Metabolic Pathways to Delay Fatigue Onset and Accumulation
Stable pH homeostasis serves as the fundamental prerequisite for normal metabolism, muscle contraction, and energy synthesis. Acid-base imbalance during exercise disrupts all metabolic pathways in skeletal muscle and exacerbates fatigue buildup. By delivering potent pH buffering effects, carnosine 6mg/2ml injection stabilizes the intracellular acid-base environment of muscle cells, thereby preserving normal physiological function of metabolic enzymes, ion channels, and muscle cell structures to comprehensively optimize the exercise metabolic network.First, a stable acid-base environment maintains the activity of key anaerobic metabolic enzymes such as phosphofructokinase and pyruvate kinase, preventing enzyme deactivation under acidic conditions and sustaining continuous ATP synthesis during exercise to supply sufficient energy for muscle contraction and delay energy-depletion fatigue.
Second, balanced acid-base levels preserve the regular rhythm of calcium ion release and reuptake by the sarcoplasmic reticulum, facilitating smooth excitation-contraction coupling in muscle tissue and eliminating muscle weakness and cramps caused by hydrogen ions competing for calcium binding sites.Furthermore, a stabilized intracellular microenvironment reduces mitochondrial damage induced by acidic metabolites, preserving intact mitochondrial structure and normal function to boost aerobic metabolic efficiency. This balances aerobic and anaerobic metabolism during intense exercise, significantly improving endurance and explosive power, lowering residual post-workout fatigue, and shortening physical recovery cycles.
Synergistic Antioxidation Reinforces pH Buffering Protection
High-intensity exercise not only disturbs acid-base equilibrium but also triggers massive bursts of reactive oxygen species (ROS). Acidic conditions further amplify oxidative stress, creating a vicious cycle of acidification and oxidative damage that worsens muscle cell injury and exercise fatigue. While exerting pH-buffering effects, the carnosine in the injection delivers superior synergistic antioxidant activity to provide dual protection against exercise-induced metabolic damage.On one hand, carnosine stabilizes cellular acid-base conditions to curb excessive ROS generation under acidity and block the amplification of oxidative stress responses.
On the other hand, carnosine molecules directly scavenge exercise-generated oxygen free radicals and hydroxyl radicals, chelate excess metal ions in the body, and mitigate lipid peroxidation damage to muscle cell membranes mediated by free radicals, safeguarding the structural integrity of muscle cells, mitochondria, and cell membranes.The combined effects of acid-base regulation and antioxidation deliver synergistic benefits: they rapidly correct exercise-related acid-base disorders, repair minor cellular microdamage caused by acidic environments, prevent fatigue accumulation after single bouts of intense exercise, and reduce chronic sports injuries stemming from long-term high-load training. From the dual perspectives of physical function repair and athletic state maintenance, it amplifies the exercise physiological benefits brought by pH buffering.
Improved Post-Exercise Acid-Base Recovery Accelerates Physical Rehabilitation
Under ordinary circumstances, lactic acid and hydrogen ions generated after exercise rely on hepatic and renal metabolism as well as endogenous buffering systems for elimination, resulting in slow recovery. Long-term intensive training easily causes chronic buildup of acidic metabolites, leading to physical exhaustion and deteriorated athletic performance. Exogenous supplementation with high-activity carnosine via carnosine 6mg/2ml injection enhances the body's buffering reserve capacity and drastically accelerates recovery from post-exercise acid-base imbalance.
After workouts, residual acidic metabolites continue to impair cellular function. Carnosine retained in skeletal muscle and systemic circulation continuously neutralizes leftover hydrogen ions, speeds up lactic acid catabolism and excretion, and rapidly restores stable intracellular pH in muscle cells. Compared with the body's endogenous buffering system, exogenous carnosine features higher buffering capacity and longer-lasting effects, effectively shortening the duration of post-workout muscle soreness and fatigue and enabling rapid restoration of muscle function. Meanwhile, swift normalization of the acid-base microenvironment improves systemic microcirculation, accelerating nutrient delivery and metabolic waste clearance. This creates optimal physiological conditions for muscle fiber repair and glycogen replenishment, facilitating fast physical recovery after exercise and meeting the demands of frequent, high-intensity professional training.
Discovery History
As the core active ingredient of the product, the discovery and isolation of carnosine mark a pivotal milestone in the advancement of biochemistry and exercise physiology.
In 1900, Vladimir Sergeevich Gulevich, a distinguished Russian chemist, together with his collaborator Amilajibi, conducted specialized research on nitrogen-containing muscle compounds at Kharkiv University.
They first successfully isolated this novel endogenous dipeptide from concentrated meat extracts. Leveraging mainstream meat purification technologies of the era, the research team systematically analyzed non-protein nitrogenous substances in skeletal muscle, ultimately identifying this structurally unique active peptide abundant in muscle tissue.It was named carnosine after the Latin word carnis, meaning flesh or muscle.In the early stages following its discovery, academic circles only confirmed its wide distribution in animal skeletal and cardiac muscle tissue, with its physiological functions yet to be explored.
From the late 20th century to the early 21st century, the value of carnosine in regulating exercise physiology was thoroughly investigated, leading to the development of injectable formulations. These preparations are now widely applied in athletic performance modulation and adjuvant clinical conditioning, establishing carnosine as a core functional agent for optimizing physical exercise capacity.
References
- PMC. Preclinical evidence and therapeutic perspectives on carnosine for the treatment of neurodegenerative disorders[J/OL]. 2026.
- Truemeds. Carnosine 6mg Injection 2ml[EB/OL]. 2026.
- Peptideinsight. Carnosine (beta-alanyl-L-histidine) functional characteristics and physiological mechanisms[EB/OL]. 2026.
- Jukić I, Kolobarić N, Stupin A, Matić A, Kozina N, Mihaljević Z, Mihalj M, Šušnjara P, Stupin M, Ćurić ŽB, Selthofer-Relatić K, Kibel A, Lukinac A, Kolar L, Kralik G, Kralik Z, Széchenyi A, Jozanović M, Galović O, Medvidović-Kosanović M, Drenjančević I. Carnosine, Small but Mighty-Prospect of Use as Functional Ingredient for Functional Food Formulation. Antioxidants (Basel). 2021 Jun 28;10(7):1037. doi: 10.3390/antiox10071037. PMID: 34203479; PMCID: PMC8300828.
- Carnosine.(https://en.wikipedia.org/wiki/Carnosine)
FAQ
What does carnosine do for the body?
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Carnosine is a naturally occurring dipeptide (made of the amino acids beta-alanine and histidine) found primarily in the brain and skeletal muscles. It acts as a cellular protector by neutralizing free radicals, reducing muscle fatigue during exercise, and preventing proteins from stiffening through a sugar-damaging process called glycation.
Who should not take L-Carnosine?
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Individuals with certain medical conditions or those taking specific medications should avoid L-carnosine. Specifically, pregnant or breastfeeding women, individuals with low blood pressure, and those taking antihypertensive or diabetes medications should consult a doctor before use. It should also be avoided by anyone with rare metabolic disorders like carnosinemia.
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