BAM15 Peptide

As a specific small molecule targeting mitochondria, one of the core values of BAM15 Peptide lies in its precise regulation of the body's inflamed response and targeted shield of vital organs. Its mechanism of action revolves around mitochondrial functional homeostasis. Unlike conventional anti-inflammatory substances, which primarily target single inflamed factors, BAM15 exerts its effect by regulating mitochondrial membrane permeability and stabilizing mitochondrial energy metabolism-related homeostasis, thereby addressing the root cause. This approach effectively circumvents the limitations and drug resistance issues associated with conventional anti-inflammatory substances. Its core application scenarios focus on three major areas: acute kidney injury, sepsis-related systemic inflammation, and retinal tissue shield. All three scenarios revolve around the core concepts of "inflammation regulation" and "organ shield," covering the intervention needs of organ damage in different systems. In these scenarios, BAM15 demonstrates unique and significant intervention effects. Its mechanism of action does not rely on additional auxiliary substances, offering strong specificity and low risk of side effects. The following provides a detailed analysis of its action logic and actual efficacy in specific application scenarios.

 

Our Products Description

 

BAM15 Peptide

BAM15 Tablet

BAM15 Capsules

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BAM15 COA

Certificate of Analysis
Compound name	BAM15
Grade	Pharmaceutical grade
CAS No.	210302-17-3
Quantity	38g
Packaging standard	PE bag+Al foil bag
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202601090068
MFG	Jan 9th 2026
EXP	Jan 8th 2029
Structure
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.54%
Loss on drying	≤1.0%	0.42%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.98%
Single impurity	<0.8%	0.52%
Total microbial count	≤750cfu/g	95
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	500ppm
Storage	Store in a sealed, dark, and dry place below -20°C

At the level of inflammation regulation, by precisely regulating the homeostasis of mitochondrial membrane permeability, we can effectively curb the abnormal activation and transmission of inflamed signals, inhibit the amplification of the inflamed cascade reaction from its source, reduce the infiltration of inflamed cells such as neutrophils and macrophages into renal tissue, decrease the intensity of renal interstitial inflammation, and alleviate pathological manifestations such as renal tissue edema and inflamed exudation.

At the level of apoptosis antagonism, it can precisely identify and antagonize the abnormally activated apoptosis program during ischemia-reperfusion. By stabilizing mitochondrial membrane potential and reducing the expression of apoptosis-related proteins such as the caspase family, it significantly reduces the apoptosis rate of renal parenchymal cells (especially renal tubular epithelial cells) and diminishes the extent of renal parenchymal damage.

The synergistic effect of the two can effectively alleviate pathological damage to kidney tissue and delay the progression of renal function deterioration, providing a new target for the intervention of acute kidney injury.

Its core function revolves around the pathological characteristics of sepsis, which can be specifically divided into two points: 

Regulate systemic inflamed homeostasis by precisely controlling at the mitochondrial level, inhibiting the excessive activation of systemic inflammatory responses, significantly reducing the levels of pro-inflammatory mediators such as interleukins and tumor necrosis factors in the circulatory system, breaking the closed loop formation of the "inflamed storm", reducing the continuous attack of inflamed factors on various organs of the body, and alleviating systemic inflammatory stress states.

Protecting multiple organ functions. During the progression of sepsis, the liver and kidneys, as the core organs for metabolism and excretion in the body, are most susceptible to inflamed damage and functional abnormalities. BAM15 peptide can maintain the structural integrity of liver and kidney tissues by reducing the stimulation of inflamed stress on parenchymal cells of the liver and kidneys, ensuring the normal functioning of basic metabolic and excretory functions of the liver and kidneys, reducing the probability of organ damage, and lowering the risk of multiple organ failure caused by sepsis. This provides a new approach for adjuvant intervention in sepsis.

The normal function of retinal tissue cells relies on stable mitochondrial function. However, during in vitro culture or in vivo transplantation, iPS-differentiated retinal tissue is prone to apoptosis due to environmental stress, nutritional deficiency, and other factors, leading to impaired retinal tissue function and affecting its clinical application value. This achieves protective intervention in iPS-differentiated retinal tissue by specifically regulating mitochondrial function.

The protective effect of BAM15 on iPS-differentiated retinal tissue is specifically targeted, which is mainly reflected in:

(I)Direct mechanism of action, without relying on additional nutritional supplementation or antioxidant assistance, can directly penetrate retinal tissue cells and act on the mitochondria within the cells. By regulating the energy metabolism state of the mitochondria, it inhibits the abnormal activation of the apoptosis signaling pathway, reduces the number of apoptotic cells, effectively maintains the structural integrity and cellular activity of retinal tissue, and avoids retinal function impairment caused by massive cell apoptosis;

(II)Specific advantage: This protective effect exhibits high cellular selectivity, acting only on abnormally apoptotic retinal cells without interfering with the physiological functions and metabolic activities of normal retinal cells, thus avoiding damage to normal tissues.

This characteristic provides important technical support for the in vitro culture, long-term preservation, and clinical transplantation application of iPS-differentiated retinal tissue, and also offers a new direction for the intervention of retinal-related diseases.

In summary, BAM15 peptide, with mitochondrial function homeostasis regulation as its core, demonstrates clear and unique efficacy in the fields of inflammation regulation and organ protection. For acute kidney injury, it breaks the injury cycle caused by ischemia-reperfusion by precisely regulating mitochondrial membrane permeability, inhibiting inflamed cascade reactions, and antagonizing apoptosis, effectively reducing renal histopathological damage and providing a new target for intervention in this condition.

In the face of sepsis and systemic inflammation, it can curb the formation of inflamed storms, reduce the levels of pro-inflammatory mediators in the circulatory system, while protecting the structure and function of core organs such as the liver and kidneys, reducing the risk of multi-organ damage and functional failure, and opening up new paths for adjuvant intervention in sepsis. For iPS-differentiated retinal tissue, it can directly act on mitochondria, inhibit abnormal cell apoptosis, and does not interfere with the physiological functions of normal retinal cells, providing important support for the in vitro culture, preservation, and related disease intervention of retinal tissue. Overall, BAM15, with its unique mechanism of action, high specificity, and low risk of side effects, demonstrates great application potential and clinical value in the field of inflammation-related organ damage intervention, providing new ideas and directions for the treatment and research of related diseases.

• Is BAM15 safe to take?

Overall, the safety profile of BAM15 is encouraging, with its remarkable tolerability, lower cytotoxicity, selective depolarization of mitochondria, and lack of detrimental effects on various tissues.

• Does BAM15 burn fat?

BAM15 helped the mice burn more calories from their food to power their cells even during resting! Thus, they lost more unhealthy body fat than mice on a traditional "diet." BAM15 improved the health of the mice with obesity in other ways, too. They burned unhealthy fat stored in their liver.

• What does BAM15 do?

As a potent and selective mitochondrial uncoupler, BAM15 disrupts the coupling between electron transport and ATP synthesis in mitochondria, leading to increased mitochondrial respiration and metabolic activity.

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