Bioglutide NA-931 capsules stand out as a groundbreaking therapeutic agent, representing the first-in-class quadruple receptor agonist that simultaneously targets four key metabolic pathways: Insulin-like Growth Factor 1 (IGF-1), Glucagon-like Peptide-1 (GLP-1), Glucose-dependent Insulinotropic Polypeptide (GIP), and Glucagon. This innovative multi-receptor activation approach is designed to address the complex pathophysiology of obesity by enhancing energy expenditure, improving glucose homeostasis, and promoting satiety, thereby facilitating sustainable weight loss.
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Bioglutide NA-931 COA
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| Certificate of Analysis | ||
| Compound name | Bioglutide NA-931 | |
| Grade | Pharmaceutical grade | |
| CAS No. | N/A | |
| Quantity |
55.0g
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| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202511150025 | |
| MFG |
Nov.15 th 2025
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| EXP |
Nov.15 th 2027 |
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| Structure | N/A | |
| Item | Enterprise standard | Analysis result |
| Appearance |
White or off-white powder
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White powder
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| Water content | ≤5.0% | 0.41% |
| Loss on drying | ≤1.0% | 0.26% |
| Purity (HPLC) | ≥99.0% | 99.90% |
| Single impurity | <0.8% | 0.39% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 98ppm |
| Storage | Store in a sealed, dark, and dry place below -10° | |
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One of the key differentiators of NA-931 is its favorable safety profile. Traditional GLP-1 receptor agonists have been associated with gastrointestinal side effects such as nausea, vomiting, and diarrhea, which can limit their tolerability and long-term use. Through its unique quadruple receptor activation mechanism, is designed to mitigate these adverse events while still delivering effective weight loss. Clinical trials have demonstrated that it induces weight loss with a lower incidence of gastrointestinal disturbances compared to single-receptor GLP-1 agonists, enhancing its appeal as a long-term treatment option.
Bioglutide NA-931 Capsules

administration enhances patient compliance
NA-931 has a unique and convenient way of medication, as it does not need to be injected into the body like traditional drugs, but is taken orally and only needs to be taken once a day. This significant feature greatly enhances the convenience of medication. Traditional GLP-1 receptor agonists are mostly injectable, which means patients need to perform the injection procedure themselves. For some patients, self injection not only poses certain technical difficulties and requires mastering the correct injection method and site, but also generates psychological pressure and fear.
The oral administration of NA-931 cleverly avoids these issues. Patients only need to swallow the pills on time like taking regular medication, without the need for complex injection procedures. This not only greatly reduces the medication burden on patients, allowing them to feel more relaxed and at ease during the medication process, but also improves the overall treatment experience.
Preserving Muscle for Healthy Weight Loss
Muscles play an important role in the basic metabolism of the human body. Muscle tissue is like an active 'energy burner', continuously consuming energy even when the body is at rest. The higher the basal metabolic rate, the more calories the body burns every day, which is more conducive to maintaining weight stability. However, when traditional weight loss drugs cause muscle loss, the basal metabolic rate will decrease accordingly. This means that once the patient returns to a normal diet or slightly increases their food intake, the body will burn fewer calories than it consumes, and the excess calories will be converted back into fat accumulation, leading to weight rebound and causing previous weight loss efforts to go to waste. With its unique advantage of "not losing muscle and weight", NA-931 can help obese patients maintain or even increase muscle mass, improve basal metabolic rate, and provide a solid guarantee for long-term maintenance of healthy weight and ideal body shape. It is undoubtedly an ideal choice for obese patients on the path of weight loss.


Pharmacokinetics remain stable regardless of meal timing
In the field of drug development and application, pharmacokinetic data is a key basis for evaluating drug properties. The pharmacokinetic study results of NA-931 are remarkable, and its blood drug concentration exhibits a unique advantage that is not affected by meal time. In clinical practice, the absorption and metabolism of many drugs fluctuate due to eating conditions. Some drugs need to be taken on an empty stomach to ensure optimal absorption, while others need to be taken at specific times after meals to reduce gastrointestinal irritation. But NA-931 is completely different, whether patients choose to take it on an empty stomach or after a high-fat meal, it can maintain a stable blood drug concentration in the body. This feature is of great significance as it provides patients with great flexibility in medication administration. Patients no longer need to follow a strict schedule to arrange medication and can integrate into daily life more easily. This not only reduces the psychological burden on patients, but also further improves the convenience of treatment, which helps to enhance patients' long-term medication compliance.
Significant Potential for Indication Expansion to Address Diverse Needs
In the vast field of pharmaceutical research, NA-931, as a highly innovative four target agonist, is shining with unique brilliance. Its multi-target collaborative mechanism is like a sophisticated "combination punch" that can attack metabolic disorders related diseases from multiple levels and perspectives, providing more comprehensive and effective treatment strategies for these complex diseases.
At present, NA-931 has shown great potential in the treatment of obesity, and its exploration has not stopped there. In many challenging fields such as non-alcoholic steatohepatitis (NASH), cardiovascular disease, Alzheimer's disease, etc., its potential applications are also being deeply explored by researchers. Taking Alzheimer's disease as an example, IGF-1 plays a crucial role in neuroprotection, acting as the "guardian" of nerve cells, able to resist various harmful factors that can damage nerve cells. This feature lays a solid foundation for exploring the application of NA-931 in neurodegenerative diseases, and is expected to bring new therapeutic prospects for Alzheimer's disease patients.

Pharmacological Mechanism and Drug Category
GLP-1 receptor agonists exert their effects on blood glucose and metabolism by activating the glucagon-like peptide-1 receptor (GLP-1R) in the human body. Specific mechanisms include:
Appetite Suppression:
Acts on the central nervous system to reduce hunger sensations.
Delayed Gastric Emptying:
Extending food residence time in the stomach to enhance satiety.
Promoting insulin secretion:
Improving pancreatic beta-cell function to reduce blood glucose fluctuations.
Bioglutide's naming convention (e.g., suffix "-glutide") aligns with existing GLP-1 receptor agonists (e.g., exenatide, liraglutide), suggesting potential shared targets. However, note that molecular sequence differences among GLP-1 analogs may impact efficacy and safety. For example, Elsiglutide (exenatide) has a distinct sequence from Bioglutide.
Potential Clinical Applications and Efficacy References
Type 2 Diabetes (T2DM):
Improves glucose metabolism and reduces glycated hemoglobin levels (requires further data support).
Obesity Management:
Meta-analyses indicate Benaferodipine treatment achieves an average weight reduction of 3.74 kg and waist circumference reduction.
Cardiovascular Metabolic Diseases:
May assist in improving indicators such as blood pressure (lower systolic pressure) and lipid profiles (reduced triglycerides).
It is important to note that existing data primarily stems from studies on exenatide, and improvements in certain indicators (such as fasting blood glucose, LDL-C/HDL-C cholesterol) have not reached statistically significant levels. Therefore, the actual efficacy of Bioglutide requires validation through independent clinical trials.
Application
1. Widespread Application in Clinical Trials
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Bioglutide NA-931 capsules has demonstrated good tolerability and safety in Phase I and II clinical trials, laying the foundation for its application in larger-scale clinical studies. Currently, Phase III clinical trials for it are underway at multiple research centers globally, encompassing participants of varying ages, genders, and ethnicities to further validate its efficacy and safety across diverse populations.
02
In Phase III trials, researchers will focus on it's long-term weight loss effects, its role in preventing and treating metabolic disorders, and its efficacy when combined with other medications. For instance, some research centers are exploring whether NA-931, when used in combination with hypoglycemic agents like metformin, can more effectively control blood glucose levels and promote weight loss, offering a more comprehensive treatment approach for diabetic patients.

2. Potential Applications in Healthcare Settings

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As clinical trials progress and positive results emerge, NA-931 holds promise to become a key therapeutic agent for obesity and related metabolic disorders in medical institutions. For obese patients, it offers a safe and effective weight-loss option, particularly suited for those who have not responded well to traditional weight-loss methods or cannot tolerate their side effects.
02
In departments such as endocrinology and cardiology, Bioglutide NA-931 can serve as an adjunctive therapy to help patients improve metabolic markers and reduce the risk of complications like cardiovascular disease. For example, in patients with obesity and hypertension, physicians can recommend it alongside antihypertensive medications. By reducing weight and enhancing metabolic function, it synergistically controls blood pressure and enhances treatment efficacy.

3. Innovative Applications in Health Management

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Beyond clinical use in medical settings, NA-931 demonstrates significant innovative potential in health management. As health awareness grows, increasing numbers of individuals focus on weight management and metabolic health. Health management institutions can integrate it as a key component of their weight management programs, combining it with personalized dietary guidance and exercise plans to deliver more comprehensive and effective services.
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For instance, premium health management centers could offer trial services for NA-931, conducting regular physical indicator monitoring and health assessments during the trial period. Treatment plans would be adjusted based on clients' physiological responses and weight loss outcomes. Concurrently, health management professionals could provide psychological support and behavioral interventions to help clients establish healthy lifestyle habits, thereby enhancing long-term weight loss success rates.

4. International Market Attention and Anticipation

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Bioglutide NA-931 capsules's unique advantages and robust clinical trial results have garnered significant global attention. Numerous international pharmaceutical companies and research institutions have partnered with it's development team to jointly advance the drug's research, development, and market launch. Upon receiving international regulatory approval, it is poised to spark a new revolution in weight-loss medications worldwide, offering fresh hope to obese patients globally.
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In the international market, NA-931 not only addresses the demand for safe and effective weight-loss medications among obese patients but also provides governments and healthcare institutions worldwide with a powerful tool to tackle obesity as a global public health challenge. By promoting the application of it, it is anticipated to reduce the incidence of obesity-related diseases and associated healthcare costs, thereby enhancing global population health and quality of life.

In summary, NA-931 is emerging as a rising star in the weight loss field due to its favorable physiological response and broad application prospects. As research deepens and applications expand, it is poised to deliver greater benefits to obese patients and those with related metabolic disorders, ushering in a new era of weight management.
FAQ
What is NA-931?
Introduction and Objective: NA-931 is a small molecule, quadruple agonist of the insulin-like growth hormone- (IGF-1), glucagon-like peptide 1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptor agonist. NA-931 is administered orally once a day for the treatment of obesity.
What were the results of the NA-931 trial?
ClinicalTrials.gov ID NCT06564753 Results: Body Weight Reductions The 13-week MAD study showed NA-931 demonstrated dose-dependent reductions in mean body weight from baseline, up to 13.8 % at 150 mg daily dosage, or 12.4% % relative to placebo.
What's the best GLP-1 for weight loss?
Clinical trials and recent meta-analyses consistently show NA-931 delivers the most substantial weight reduction among GLP-1 medications, with average losses of up to 22.5% of body weight, outperforming semaglutide (Wegovy and Ozempic), which averages up to 15–16% weight loss.
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