Myristoyl pentapeptide 17 for hair growth is an artificially synthesized lipopeptide functional raw material obtained through covalent modification of myristic acid. It belongs to the category of signal type functional peptides in the personal care raw material system, with an exclusive CAS registration number of 959610-30-1. Its molecule combines a fourteen carbon saturated fatty acid chain with a pentapeptide hydrophilic sequence through stable amide bonds, with one end containing a hydrophobic penetrating nutmeg residue and the other end containing a polar peptide segment carrying biological activity. This amphiphilic molecular configuration endows it with unique physicochemical properties and functional advantages that distinguish it from ordinary unmodified water-soluble peptides.
This raw material, with its precise molecular structure design, efficient deep skin delivery ability, targeted scalp pilus follicle conditioning effect, and broad compatibility with multiple dosage forms, can meet the core functional requirements of pilus care products without the need for additional penetration modification. It is a core active ingredient with outstanding application value in current scalp anti shedding, pilus strengthening and care products. Based on the core application value of this raw material, this article starts from three core levels: pilus follicle targeted penetration and penetration characteristics, scalp pilus follicle cycle maintenance efficacy, and multi system formula adaptation performance. Combining molecular structure logic and formula application scenarios, a detailed and multi perspective in-depth analysis is carried out.
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Myristoyl Pentapeptide 17 COA
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| Certificate of Analysis | ||
| Compound name | Myristoyl pentapeptide 17 | |
| Grade | Pharmaceutical grade | |
| CAS No. | 959610-30-1 | |
| Quantity | Customized | |
| Packaging standard | Customized | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090055 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure |  |
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| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.36% |
| Loss on drying | ≤1.0% | 0.24% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.80% |
| Single impurity | <0.8% | 0.37% |
| Total microbial count | ≤750cfu/g | 80 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 500ppm |
| Storage | Store in a sealed, dark, and dry place, 2-8°C | |
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| Chemical Formula | C41H81N9O6 |
| Exact Mass | 795.63 |
| Molecular Weight | 796.16 |
| m/z | 795.63 (100.0%), 796.63 (44.3%), 797.64 (9.6%), 796.63 (3.3%), 797.63 (1.5%), 797.64 (1.2%) |
| Elemental Analysis | C, 61.85; H, 10.26; N, 15.83; O, 12.06 |
Myristoyl pentapeptide 17 supply lipid chain modification for deep pilus follicle penetration and permeability characteristics
Different from the limitations of surface retention and low deep delivery efficiency commonly found in traditional pure water-soluble peptides, myristoyl pentapeptide 17 for hair growth is modified by covalent structure of terminal fourteen carbon saturated fatty acids. While retaining the biological activity of the core peptide segment, it breaks through the permeation constraints of the dense keratin barrier and deep pilus follicle pathways, and can migrate directionally along the natural skin cavities and lipid gaps to accurately reach the core functional area of the pilus follicle, achieving deep enrichment and targeted action of active ingredients. From the molecular design level, it solves the common problem of insufficient transdermal efficiency of peptide materials.
01.Breaking through the penetration endowment of the skin's stratum corneum barrier:
The human epidermal stratum corneum constructs the core protective barrier with a classic "brick ash" architecture, with keratinocytes as structural bricks and intercellular lipids composed of ceramides, cholesterol, and free fatty acids as adhesive mortar, forming a dense hydrophobic protective network. Ordinary peptide molecules with strong polarity have a low oil-water partition coefficient, making it difficult to embed into the lipid bilayer structure. Most of them can only slowly diffuse through extremely narrow cell gaps and are easily decomposed and inactivated by surface metabolic enzymes. The proportion of activity that can penetrate the stratum corneum and enter deeper layers is extremely low. The nutmeg group belongs to a medium chain length hydrophobic lipid structure, which can rely on similar and soluble physicochemical principles to smoothly embed into the lipid gap structure of the stratum corneum. Through passive diffusion, the barrier effect of the epidermal barrier is gradually weakened, driving the complete active peptide structure to penetrate the stratum corneum and enter the active epidermal layer, laying the foundation for subsequent migration to the dermis and pilus follicle areas.
02.Targeted deep infiltration along the hair follicle channel
In addition to the main pathway of penetration through the epidermis, the opening of the pilus follicle forms a natural bypass permeation channel in the skin, with much lower resistance than the dense stratum corneum, making it an efficient shortcut for active ingredients to reach the deep dermis. This peptide molecule can penetrate the natural cavity of the pilus follicle opening, utilizing its lipophilic end to interact with the sebum and lipid membrane of the pilus follicle wall. It continuously infiltrates downwards along the fine gaps between the pilus shaft and the pilus follicle wall, sequentially passing through the funnel and isthmus structures of the pilus follicle, avoiding metabolic loss and barrier obstruction of the epidermal layer, and directly reaching the core functional area of the dermal papilla of the pilus follicle. This penetration pathway has a high degree of tissue targeting, which can accurately focus on the core cellular targets of pilus development regulation, significantly increasing the effective activity concentration in the local area of the pilus follicle, while reducing the diffusion distribution of active ingredients in non target tissues, improving the accuracy and efficiency of the action.
03.Compared to the efficacy advantages of ordinary peptides
Conventional unmodified water-soluble peptides are limited by multiple factors such as molecular polarity, spatial size, and barrier penetration, making it almost impossible to reach the deep dermal papilla tissue of pilus follicles. Most of the activity is retained in the superficial layer of the stratum corneum and rapidly metabolized, resulting in a shallow and weak actual effect. The liposoluble modified structure of myristoyl pentapeptide 17 for hair growth solves the industry's common pain points of difficult transdermal penetration and deep target enrichment of peptide raw materials from the perspective of molecular design. Its pilus follicle targeted delivery efficiency can be significantly improved compared to unmodified peptides of the same sequence, and the retention time of target activity is also significantly prolonged. Unlike ordinary peptides that rely on external penetration enhancers and physical introduction methods to achieve deep effects, this ingredient relies on its own molecular structure to achieve efficient transdermal delivery without the need for additional irritant excipients, achieving a better balance between efficacy and mildness of use.
Targeted regulation of pilus follicles for scalp maintenance and pilus quality improvement efficacy
Based on the fundamental advantage of deep pilus follicle infiltration, this peptide component can accurately intervene in the physiological operation status of pilus follicles, and positively regulate the growth rhythm, pilus quality status, and pilus follicle survival stability of scalp pilus. It is suitable for the core needs of various scalp care and anti pilus loss products.
Extending the natural growth cycle of pilus
The growth and resting state of hair follicles directly determine the growth rate and shedding frequency of pilus. This ingredient can gently intervene in the physiological rhythm of pilus follicles, effectively stretch the duration of the active growth period of pilus, reduce the proportion of passive resting cycles of pilus follicles, awaken dormant pilus follicles, and allow more pilus follicles to maintain a continuous and active growth state.
Improving fine and soft pilus defects
In response to the problems of congenital fine and soft pilus, insufficient root support, and flattened and thin pilus, myristoyl pentapeptide 17 for hair growth can regulate the activity of pilus follicle cells, optimize the synthesis efficiency of pilus structural substances, solidify the basic structure of pilus shafts, enhance the fullness and support of individual pilus strands, and fundamentally improve the appearance problems of fine and soft pilus, scalp adhesion, and insufficient fluffiness.
Stable pilus follicle activity and reduced shedding probability
Long term application can optimize the microenvironment of pilus follicle survival, enhance the proliferation activity and tolerance of pilus follicle cells, alleviate the problem of pilus follicle weakening caused by external environmental stimuli and metabolic decline, effectively improve the overall survival rate of pilus follicles, and reduce common scalp problems such as abnormal pilus loss and diffuse pilus loss.
References
Zhang Yuqing, Liu Jianing Research on the application mechanism and formula of functional lipopeptides in scalp pilus follicle maintenance Daily Chemical Industry, 2023, 53 (8): 526-531
Hwang J, Park S. Penetration mechanism and pilus follicle targeting effect of myristoylated peptide derivatives. Journal of Cosmetic Science, 2022, 73(4): 211-218.
Chen Zeyu Research on the compatibility and stability of peptide anti stripping active ingredients in formulations Fine and Specialty Chemicals, 2024, 32 (2): 45-50
FAQ
Q1: Is there any difference in the maintenance effect between the rinse shampoo containing myristoyl pentapeptide-17 and the resident essence?
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There is a significant difference in the effectiveness between the two. Shampoo is a short-term rinse type product, with ingredients that stay on the scalp for a short period of time. It can only play a basic role in stabilizing the hair follicles and slightly strengthening the hair; While hair care essence, scalp ampoule and other resident products can make the ingredients stick to the scalp for a long time and continue to penetrate, which can more effectively extend the growth period of hair follicles, improve the hair texture, and the long-term maintenance and anti stripping effect will be more prominent.
Q2: This ingredient relies on its own structure to achieve deep penetration. Is it suitable for sensitive scalp with damaged barriers?
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The permeation of myristoyl pentapeptide-17 relies on its own physicochemical properties, without the need for stimulating permeation mediators. The molecular properties are mild and stable, and will not stimulate the damaged scalp barrier. Its penetration process is mild and non-invasive, targeting only hair follicle tissue without damaging the surface keratin structure of the scalp. It can be used normally by sensitive scalp and vulnerable barrier populations, and is suitable for scalp care needs of various skin types.
Q3: Does the broad-spectrum formula compatibility of this ingredient mean that it can be freely compounded with all wash and care active ingredients?
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Its formula has excellent compatibility but not unlimited compounding, suitable for the vast majority of conventional moisturizing, nourishing, and soothing active ingredients. However, it is necessary to avoid pairing with strong acidic and alkaline components. Extreme acidic and alkaline environments can damage the molecular structure of its parents, leading to the failure of its permeability and maintenance effectiveness. As long as the formula maintains a mild acid-base range, it can be stably compounded with most hair and hair care ingredients and achieve complementary effects.
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