Dipeptide 2 Serum

Dipeptide 2 serum, is a miniature active peptide substance formed by the peptide bond condensation of two natural amino acids, valine and tryptophan. Its standard chemical identification number is CAS 24587-37-9. Different from macromolecular skincare active ingredients, this substance has natural characteristics such as ultra-fine molecular particle size, extremely low penetration resistance, and excellent biocompatibility. It can adhere to the skin's cortex without the need for penetration enhancers and exert physiological regulation effects. At the same time, it is mild in nature, non allergenic and non irritating, and has no skin burden. It is highly suitable for the special skin state of thin and tender skin around the eyes and fragile barriers. It is a highly targeted exclusive active material in fine eye skincare. 

The eye repair value of this component relies entirely on three sets of internal physiological regulation pathways that work together and perform their respective functions to achieve precise stability maintenance, without relying on superficial effects such as physical covering or surface hydration. The core mechanism includes intervening in the metabolism process of angiotensin, accurately controlling abnormal leakage of subcutaneous tissue fluid, blocking the activation process of endogenous bradykinin, reducing superficial inflammatory redness around the eyes, and activating the autonomous rhythm relaxation function of lymphatic vessels, accelerating the circulation and guidance of local body fluids and metabolic waste. From the three core dimensions of skin microcirculation, inflammation regulation, and body fluid metabolism, it systematically improves skin sub-health problems such as daily sleep disorders, eye swelling and redness caused by mild external stimuli.

 

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Dipeptide 2 COA

Certificate of Analysis
Compound name	Dipeptide 2
Grade	Pharmaceutical grade
CAS No.	24587-37-9
Quantity	Customized
Packaging standard	Customized
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202601090051
MFG	Jan 9th 2026
EXP	Jan 8th 2029
Structure
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.36%
Loss on drying	≤1.0%	0.24%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.80%
Single impurity	<0.8%	0.37%
Total microbial count	≤750cfu/g	80
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	500ppm
Storage	Store in a sealed, dark, and dry place below -20°C

Block the synthesis of angiotensin II and weaken the microvascular leakage effect

The eye area is the most unique region of the human body's skin structure, with a much thinner cortex than other parts of the face. The subcutaneous fat layer is thin, the connective tissue is loose, and the microvascular veins are highly dense. The elasticity and tolerance of the vessel walls are weak, making it a typical area of highly sensitive and low tolerance skin. Under the interference of daily factors such as staying up late fatigue, fluctuations in daily routines, excessive salt intake, and slowed local metabolism, the endogenous regulatory system of the skin is prone to imbalance, leading to a large accumulation and abnormal activation of angiotensin II. This active medium is a key trigger for inducing microcirculation disorders and microvascular wall dysfunction in the eye, which directly leads to increased vascular leakage and abnormal accumulation of subcutaneous fluid, ultimately resulting in visible swelling, protrusion, and edema problems. Dipeptide 2 serum can accurately target and intervene in the metabolic regulation system of skin microvessels, intervening in the entire chain from upstream signal transduction, midstream enzyme activity regulation, and downstream vascular state maintenance, to fundamentally prevent the occurrence and recurrence of leakage type edema.

-Blocking the endogenous pathway of angiotensin II production: Angiotensin converting enzyme is widely present in the human dermis and subcutaneous superficial tissues. This enzyme is a key catalytic mediator that maintains the angiotensin metabolism cycle. Under normal circumstances, it steadily promotes the cleavage and transformation of angiotensin precursor substances, producing biologically active angiotensin II. When the skin is in a state of fatigue stress, the activity of this conversion enzyme becomes abnormally high, leading to excessive accumulation of angiotensin II, which continuously stimulates the smooth muscle tension of microvessels, disrupts the dynamic balance between vasodilation and contraction, and disrupts the stable state of the ocular microvascular system. Dipeptide-2 can quickly reach the target of microvascular action with the advantage of small molecule permeation, specifically antagonizing the catalytic efficiency of angiotensin-converting enzyme, significantly weakening its substrate conversion ability, and effectively blocking the excessive synthesis and local enrichment of angiotensin II. By inhibiting abnormal activation of blood vessels under stress, avoiding imbalanced reactions such as sustained stress, tension, and dilation of blood vessels, stabilizing the physiological stability of microvessels around the eye, and cutting off the core cause of abnormal leakage of tissue fluid from upstream sources, a solid foundation barrier is built for fluid balance around the eye.
-Lowering the microvascular permeability threshold and inhibiting tissue fluid leakage: Excessive accumulation of angiotensin II will continue to stimulate the microvascular endothelial structure, significantly increasing the permeability threshold of the microvascular wall, breaking the regular structure of tight endothelial cell connections, resulting in abnormal widening of vascular cell gaps and decreased vascular wall density. After the abnormal increase in vascular permeability, water-soluble tissue fluid inside the blood vessels will break through the wall barrier and infiltrate into the subcutaneous loose interstitial layer in an disorderly manner. Long term accumulation without timely aging will lead to persistent eye swelling and bloating. Dipeptide 2 serum can act on the microvascular endothelial cell community, repair and reshape the regular arrangement of endothelial cells, tighten cell gaps, enhance vascular wall density, effectively downregulate the passive permeability of microvessels, and significantly reduce the risk of fluid leakage. By precise control of vascular leakage behavior, abnormal accumulation of tissue fluid in the subcutaneous interstitium is reduced at the microscopic level, continuously maintaining the dynamic balance of subcutaneous fluid around the eyes, and improving eye skin problems such as swelling and swelling caused by vascular leakage.

Antagonistic bradykinin activity, resolving superficial inflammatory redness around the eyes

Bradykinin is an endogenous inflammatory mediator in human skin. Thin and tender skin around the eyes is susceptible to external stimuli and metabolic disorders, which can trigger excessive secretion of bradykinin, leading to superficial inflammation, redness, sensitivity, and other issues. Dipeptide 2 serum can accurately antagonize the physiological activity of bradykinin, block inflammatory signaling, and achieve a mild and soothing skincare effect. 
-Inhibiting the inflammatory cascade reaction mediated by bradykinin: Activation of bradykinin activates the local inflammatory cascade pathway in the skin, stimulating passive dilation of capillaries and abnormal local blood flow, resulting in redness and burning sensitivity around the eyes. Dipeptide-2 can bind to the active site of bradykinin, inactivate its biological activity, block the chain activation of subsequent inflammatory factors, terminate the sustained development of local mild inflammation, and quickly restore superficial redness.
-Maintaining a stable microenvironment around the eyes: Compared to conventional anti-inflammatory components, this dipeptide does not have strong irritants and can achieve anti-inflammatory and soothing effects without breaking the skin's natural barrier. It weakens the disturbance of endogenous inflammatory mediators, balances the inflammatory metabolism level of the skin around the eyes, improves the characteristics of thin and tender skin that are prone to redness and sensitivity, maintains a calm and stable skin microenvironment, and avoids recurrent superficial inflammation problems.

Chen Li, Wang Haoyu Research on the regulatory mechanism of active peptides on human skin microcirculation and vascular homeostasis [J]. Daily Chemical Industry, 2024, 54 (08): 521-527
Carey R M. Angiotensin Receptor Signaling and Cutaneous Microvascular Homeostasis[J]. Journal of Cutaneous Science, 2023, 72: 89-95.
Liu Siqi, Zhang Muchen Application mechanism of small molecule dipeptide raw materials in soothing and reducing swelling of eye skin [J]. Cosmetic Science, 2025, 09 (02): 112-118 

Hydrolysis of diepptide 2-naphthylamides by human muscle enzymes.(https://pmc.ncbi.nlm.nih.gov/articles/PMC1165234/) 

Asymmetric Michael Addition Organocatalyzed by α,β-Dipeptides under Solvent-Free Reaction Conditions (https://pmc.ncbi.nlm.nih.gov/articles/PMC6152315/)

Q3: Can the activation of lymphatic circulation only improve eye swelling, and is it suitable for other facial swelling scenarios?
A3: The lymphatic activation mechanism of this ingredient is universal, but due to its molecular compatibility and highly targeted effect on the physiological structure of the skin around the eyes, it has the best effect in regulating eye swelling. For superficial and metabolic facial edema, it can be improved by accelerating local lymphatic relaxation metabolism, but it has no significant effect on edema caused by fat accumulation and structural relaxation.

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