Bird's Nest Peptide

Bird's Nest Peptide
Details:
1.General Specification(in stock)
API(Pure powder)
2.Customization:
We will negotiate individually, OEM/ODM, No brand, for secience researching only.
Internal Code: KP-1-13/001
Bird's Nest Peptide
Manufacturer: BLOOM TECH Wuxi Factory
Analysis: HPLC, LC-MS, HNMR
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Technology support: R&D Dept.-4
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Description
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Bird's nest peptide refers to small molecule active peptides made from bird's nest as raw material by modern enzymatic hydrolysis technology to hydrolyze large molecule proteins. Its molecular weight is usually below 5000 daltons, or even smaller, and its small molecule properties may contribute to absorption. It retains the core nutrients of bird's nest such as sialic acid and exhibits functional activity. Some studies suggest that it may have anti-aging, improved skin moisture and elasticity, antioxidant or immune enhancing effects, and can be applied in functional foods, health supplements, and skincare products. As a highly processed product of bird's nest, bird's nest protein peptide are a direction for the development of the bird's nest industry.

 

Bird's nest peptid Price List | Shaanxi BLOOM Tech Co., Ltd

Bird's nest peptid Price List | Shaanxi BLOOM Tech Co., Ltd

Method of Analysis

Bird's Nest Peptide COA

Shaanxi BLOOM Tech Co., Ltd
Certificate of Analysis
Compound name Bird's Nest Peptide
Grade Pharmaceutical grade
Quantity 88g
Packaging standard PE bag+Al foil bag
Manufacturer Shaanxi BLOOM TECH Co., Ltd
Lot No. 202601090066
MFG Jan 9th 2026
EXP Jan 8th 2029
Structure N\A
Item Enterprise standard Analysis result
Appearance White or almost white powder Conformed
Water content ≤5.0% 0.40%
Loss on drying ≤1.0% 0.21%
Heavy Metals Pb≤0.5ppm N.D.
As≤0.5ppm N.D.
Hg≤0.5ppm N.D.
Cd≤0.5ppm N.D.
Purity (HPLC) ≥99.0% 99.98%
Single impurity <0.8% 0.42%
Total microbial count ≤750cfu/g 205
E. Coli ≤2MPN/g N.D.
Salmonella N.D. N.D.
Ethanol (by GC) ≤5000ppm 520ppm
Storage Store in a sealed, dark, and dry place below 2-8°C

Shaanxi BLOOM Tech Co., Ltd

Applications-

Bird's nest peptides are derived from natural bird's nest and are hydrolyzed into small molecule active peptides with a molecular weight typically below 5000 Daltons (Da) using patented enzymatic hydrolysis technology. Compared to traditional bird's nest, it exhibits superior biological activity in antioxidant activity, anti hyperglycemic properties, antibacterial properties, and angiotensin-converting enzyme inhibition (ACE-i) activity. Its core active ingredients include epidermal growth factor (EGF), colony stimulating factor (CSF), sialic acid (N-acetylneuraminic acid, also known as bird's nest acid), and more than 18 amino acids (with a total essential amino acid ratio of 44.89%, far exceeding the FAO/WHO quality protein standard).

Bird's nest peptid skin | Shaanxi BLOOM Tech Co., Ltd

1. Skin repair and anti-aging beauty - the most core application scenario
The maintenance of the skin is its most well-known and extensively researched use. The underlying mechanism can be understood from three levels:
Firstly, EGF drives cell regeneration. Rich in epidermal growth factor (EGF) analogs, this "beauty factor" recognized by the 1986 Nobel Prize in Medicine can directly activate epidermal cells, promote cell division, proliferation, and differentiation, and accelerate the renewal and repair of damaged skin. A joint study between South China University of Technology and GLYKEN has confirmed that it can be directly absorbed and utilized by cells within 5 minutes, with a nutrient utilization rate 25 times higher than traditional bird's nest.

Secondly, promote collagen synthesis. Amino acids such as glycine and proline in bird's nest protein peptides are key raw materials for synthesizing collagen, which can stimulate fibroblast activity.

Promote the generation of collagen and elastic fibers in the skin, thereby enhancing skin elasticity and reducing fine lines and wrinkles. The synergistic effect of bird's nest protein peptide and collagen peptide can significantly enhance the skin's ability to hydrate and lock in water, as well as its antioxidant properties.

Thirdly, it effectively moisturizes and whitens the skin. The glycosaminoglycans in the product have strong hydrophilicity and can deeply lock in water to maintain skin hydration; At the same time, it can promote the expression of moisturizing factor filaggrin (FLG) gene and improve skin barrier function. Research has shown that it has a good inhibitory effect on skin inflammatory factors IL-1 β, IL-6, TNF - α, COX-2, and NF - κ B, and can reduce inflammatory manifestations such as erythema, edema, and pigmentation. Verified by a 28 day human efficacy report of oral administration of bird's nest peptide: improved skin brightness by 10.89%.

Bird's nest peptid fiber | Shaanxi BLOOM Tech Co., Ltd

Source:

Baidu Health · Medical Science Popularization; YANPEP Bird's Nest Protein Peptide from Oriental Fortune Network; Zhihu · Research on bird's nest protein peptides; Minfu Kang; Dr. Bohe; China Net · GLYKEN Ke Lai Yin; Minfukang 

Bird's nest peptid function | Shaanxi BLOOM Tech Co., Ltd

2. Enhancing immune function - building the body's defense barrier
The sialic acid glycoprotein and colony stimulating factor (CSF) in bird's nest protein peptides are the core substances of immune regulation. CSF can stimulate lymphocyte division - lymphocytes are the most important immune cells in the human body; Salivary acid can promote macrophage phagocytosis and enhance antibody production. The GLYKEN research team has found that bird's nest glycoprotein can effectively supplement secreted immunoglobulin (sIgA), accurately and rapidly enhancing immunity. Clinical observations have shown that long-term use of bird's nest protein peptides can reduce the incidence of common diseases such as colds.

It is worth noting that the sialic acid content in bird's nest protein peptide can reach up to 20.03% (traditional bird's nest is only 7.64%~12.52%). From the perspective of sialic acid alone, bird's nest protein peptide are a more excellent immune supplement.

Source:

Baidu Health; Dr. Bohe; WeChat public platform · "Bird's Nest Protein Peptide and Related Products and Health: Research Overview"; China Net 

3. Antioxidants and Delaying Systemic Aging - Six Anti Aging Pathways
Its antioxidant effect has been confirmed by multiple studies: it can effectively eliminate reactive oxygen species (ROS) such as superoxide anion radicals and hydroxyl radicals, reduce malondialdehyde (MDA) levels, and enhance endogenous antioxidant enzyme activities such as superoxide dismutase (SOD) and catalase (CAT). Bird's nest protein peptides with a molecular weight less than 5000Da are more easily absorbed, with the<3000Da portion exhibiting the highest biological activity in all in vitro assays, even after incubation with gastrointestinal proteases, maintaining antioxidant activity.

More cutting-edge research suggests that its anti-aging effect precisely corresponds to six major pathways: epigenetic changes, maintaining mitochondrial health, delaying cellular aging, reducing chronic inflammation to slow down multi organ decline, and maintaining gut microbiota diversity.

Bird's nest peptid anti | Shaanxi BLOOM Tech Co., Ltd

Source: Oriental Wealth Network; Zhihu; Minfukang 

Bird's nest peptide nutritional | Shaanxi BLOOM Tech Co., Ltd

4. Promoting wound healing and tissue repair - nutritional support for postoperative rehabilitation
Collagen is the main component of granulation tissue. As an exogenous small molecule peptide, it can quickly enter the bloodstream, provide essential amino acids for damaged tissues, and accelerate collagen synthesis and deposition. The EGF it contains can shorten the inflammatory period, promote granulation tissue formation, and accelerate wound repair. Clinical data shows that supplementing bird's nest protein peptides to postoperative or frail individuals can accelerate wound healing, alleviate fatigue, and improve gastrointestinal and respiratory mucosal health. The "Preparation Method of Bird's Nest Protein Peptide for Promoting Cell Repair, High Moisturizing and Whitening Effects" (Patent No. ZL 2022 11398048.3), which was granted a national invention patent in 2024, further confirms its application value in the field of tissue repair.

Source: Baidu Health; Oriental Wealth Network; Dr. Bohe 

5. Guarding Bone and Joint Health - Daily Companion for Middle aged and Elderly People
Joint cartilage contains a large amount of collagen. Hydroxyproline can promote cartilage matrix synthesis and alleviate joint friction; In vitro activity analysis showed that it has a significant effect on inhibiting rheumatoid arthritis. Meanwhile, proteoglycans can protect joint cartilage. The calcium binding sites in collagen peptides contribute to mineral deposition, and continuous intake may increase bone density and reduce the risk of osteoporosis. The 28 day human efficacy report of Yanzhiwu shows that bird's nest peptide can improve physical fatigue by 35.67%.

Bird's nest peptide bone | Shaanxi BLOOM Tech Co., Ltd

Source: Baidu Health; Oriental Wealth Network; Dr. Bohe 

Bird's nest peptide Brain | Shaanxi BLOOM Tech Co., Ltd

6. Brain strengthening, intelligence enhancement, and sleep improvement - deep nourishment of the nervous system
Salivary acid is an important component of gangliosides, and the sialic acid content of neuronal membranes is 20 times higher than that of other cells. Exogenous sialic acid can increase the concentration of gangliosides in the brain, enhance learning ability and cognitive level. The experiment showed that the learning ability of rats treated with sialic acid was significantly better than that of the control group. Bird's nest protein peptide also has the effect of calming and calming the nerves. After 28 days of oral administration, it has been verified to improve sleep quality by 28.81% and memory by 6.62%. Its rich amino acids such as tryptophan help stabilize emotions, reduce anxiety, and create a physical and mental state conducive to falling asleep.

Source: Baidu Health; Oriental Wealth Network; WeChat public platform 

7. Anti inflammatory and anti allergic - a new choice for atopic dermatitis
The study published in Frontiers in Pharmacology in 2022 clearly stated that consuming bird's nest has anti-inflammatory effects and can restore symptoms of atopic dermatitis. Its signal cascade analysis revealed the regulatory effects of bird's nest protein peptide on multiple inflammatory pathways. Domestic patent research further confirms that bird's nest protein peptide have good inhibitory effects on inflammatory factors such as IL-1 β, IL-6, TNF - α, COX-2, and NF - κ B, and can significantly inhibit degranulation of mast cells (mast cells are inflammatory effector cells widely distributed around subcortical microvessels). The high-dose group of bird's nest protein peptide can significantly reduce the duration of scratch marks on injured skin in mice, as well as the occurrence of indicator inflammations such as erythema, edema, exudation, and epidermal peeling. This means that bird's nest protein peptide can not only be used for skin inflammation, but also as food/health supplements to eliminate gastrointestinal inflammation.

Bird's nest peptide skincare | Shaanxi BLOOM Tech Co., Ltd

Source: Oriental Wealth Network; Zhihu 

Discovering History

The research on bird's nest protein peptide is a field in which the bird's nest industry is developing from traditional empirical applications to quantifiable and verifiable precision nutrition. Its development process began with the exploration of enzymatic hydrolysis technology for large molecular proteins in bird's nest, aiming to obtain small molecule active peptides.

 

Around 2015, relevant institutions began researching the enzymatic hydrolysis technology of bird's nest protein peptides.

 

In 2020, "Bird's Nest Active Peptides and Their Antitumor Applications" obtained a national invention patent (patent number: ZL201910619230.9).

 

On October 31, 2021, Guangxi released the first local standard for bird's nest protein peptide, "Technical Regulations for the Production of Bird's Nest Protein Peptide" (DB45/T 2371-2021).

 

In January 2022, the Bird's Nest Protein Peptide Research Center was established to systematically carry out research on bird's nest protein peptide enzymatic hydrolysis technology, active ingredients, and functions.

 

From 2021 to 2023, relevant research teams have collaborated with universities such as Jiangnan University, Hong Kong University of Science and Technology, and South China University of Technology to conduct research on the whitening, anti skin inflammation, and skin repair functions of bird's nest protein peptide. The relevant results have been published in international academic journals such as Gels, Frontiers in Pharmacology, and Journal of Agricultural and Food Chemistry.

 

In 2024, relevant research successfully resolved the unique molecular structure of bird's nest protein peptide and found that sialic acid glycopeptides can pass through the blood-brain barrier and placental barrier.

 

In the same year, a method and application for preparing bird's nest protein peptide with promoting cell repair, high moisturizing and whitening effects was granted a national invention patent (patent number: ZL 2022 11398048.3).

 

A total of 60 research papers related to bird's nest protein peptide have been published, including 19 international SCI papers.

 

In 2025, the group standard "Good Manufacturing Practice for bird's nest protein peptide" will be led in drafting to promote the standardized development of the industry.

The research on bird's nest peptides has entered a stage characterized by clear molecular structures, clear mechanisms of action, and quantifiable clinical data, continuously promoting the scientific and industrial development of the bird's nest industry.

 

References:

 

Baidu Health · Medical Science Popularization
Dr. Bohe's official website( http://www.bohe.cn )
WeChat Public Platform (Tencent) · "Bird's Nest Peptides and Related Products and Health: Research Overview" (Modern Food Technology 2024, 40 (09): 388-397)
Oriental Wealth Network · YANPEP Bird's Nest Peptide
China Net · GLYKEN
Frontiers in Pharmacology 2022
Food Bioscience 2023
Journal of Photochemistry & Photobiology(SCI)
National Invention Patent ZL 2022 11398048.3
39 Health Network
Minfukang
99 Health Network

 

FAQ

What is bird nest peptide?

Edible bird's nest peptide (EBNP) was prepared by hydrolyzing edible bird's nest using alkaline protease. The EBNP was dominated by oligopeptides and had 6.64% sialic acid. The EBNP had antioxidant capacity at biochemical and cellular levels.

 

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