Secretin Injection

Secretin is the first gastrointestinal hormone discovered in humans, is primarily secreted by S cells in the duodenum and serves as a key regulatory molecule in maintaining the normal function of the digestive system. Secretin Injection,its most essential physiological functions are twofold: first, stimulating the pancreas to secrete alkaline pancreatic juice, effectively neutralizing gastric acid that enters the intestines; and second, inhibiting gastric acid secretion while delaying gastric emptying. These two mechanisms complement each other, jointly establishing a defense system for gastrointestinal acid-base balance.

This mechanism holds significant physiological importance: on one hand, it creates a suitable alkaline environment for the activation of intestinal digestive enzymes, ensuring digestive efficiency; on the other hand, it prevents excessive gastric acid from damaging the intestinal mucosa, thereby preserving the integrity of the digestive tract. The function of it is not isolated-it works synergistically with hormones such as cholecystokinin and is regulated by the nervous system, collectively maintaining digestive homeostasis.

Therefore, by precisely regulating acid-base balance, it plays an indispensable pivotal role in the digestive process. The proper functioning of secretin is a critical foundation for the smooth digestion and absorption of food.

 

Our Products Description

 

Secretin Peptide

Secretin Acetate

Secretin Injection

Secretin Tablet

Secretin COA

Certificate of Analysis
Compound name	Secretin
Grade	Pharmaceutical grade
CAS No.	17034-35-4
Quantity	30g
Packaging standard	PE bag+Al foil bag
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202501090077
MFG	Jan 9th 2025
EXP	Jan 8th 2028
Structure
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.54%
Loss on drying	≤1.0%	0.42%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.97%
Single impurity	<0.8%	0.52%
Total microbial count	≤750cfu/g	95
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	500ppm
Storage	Store in a sealed, dark, and dry place below -20°C

The function of this drug has been the core focus of clinical application and scientific research since its discovery. Based on this physiological effect, mature diagnostic methods, targeted adjuvant treatment plans, and cutting-edge scientific research directions have been extended.

(I)Clinical Diagnosis: Detailed Application of the Secretin Stimulation Test

This drug stimulation test is currently one of the gold standard methods for assessing pancreatic exocrine function. Its design is entirely based on the classic physiological role of it. The test procedure is as follows: under fasting conditions, synthetic exogenous secretin injection is administered intravenously to precisely activate relevant receptors on pancreatic ductal epithelial cells. Subsequently, pancreatic juice secreted within a specified timeframe is collected via endoscopic pancreatic duct catheterization or duodenal aspiration. Quantitative measurements are then performed on the total volume of pancreatic secretion, bicarbonate concentration in the pancreatic juice, and the levels of digestive enzymes such as pancreatic amylase, lipase, and trypsin.

Under normal physiological conditions, exogenous secretin stimulates the pancreas to produce an adequate volume of pancreatic juice with high bicarbonate concentration. However, when the pancreas is affected by organic diseases, its exocrine function may be impaired to varying degrees. By detecting abnormalities in these parameters, the test provides crucial diagnostic support for conditions such as chronic pancreatitis, pancreatic cancer, cystic fibrosis, and pancreatic exocrine insufficiency. Particularly for early-stage pancreatic lesions, this test can detect functional decline before significant abnormalities appear on imaging studies, thereby improving early disease diagnosis rates.

(II)Clinical Treatment: Auxiliary Intervention for Pancreatic Exocrine Insufficiency

This treatment approach is only applicable to specific patient populations with severe loss of pancreatic exocrine function, commonly seen in cases such as extensive pancreatic resection, advanced chronic pancreatitis, or cystic fibrosis with pancreatic damage. In these patients, endogenous secretin secretion is insufficient, or the sensitivity of pancreatic ductal epithelial cells to it is reduced, resulting in inadequate secretion of alkaline pancreatic juice. Exogenous supplementation of this drug directly stimulates the remaining pancreatic tissue to secrete bicarbonate, raising the duodenal pH and neutralizing gastric acid entering the intestines. On one hand, this helps prevent strong gastric acid from continuously eroding the intestinal mucosa, reducing the risk of intestinal ulcers and bleeding.

On the other hand, it provides an optimal neutral-to-alkaline environment for the activity of exogenous pancreatic enzyme preparations. In clinical practice, secretin injection is often used in combination with exogenous pancreatic enzyme supplements to effectively alleviate symptoms such as steatorrhea, bloating, and loss of appetite caused by pancreatic enzyme inactivation and impaired digestive function. This approach enhances the absorption efficiency of fats, proteins, and carbohydrates, improving the patient's nutritional status. It is important to note that this treatment is only an auxiliary measure and cannot reverse organic pancreatic damage or replace curative treatments such as pancreatic transplantation.

On one hand, screening for agonists that mimic the effects of it aids in developing safer and more effective pancreatic function replacement drugs. On the other hand, screening for modulators such as secretin receptor antagonists explores their potential applications in diseases related to pancreatic hypersecretion, providing theoretical and experimental foundations for the development of new drugs targeting pancreatic disorders.

The role of it plays an auxiliary role in the prevention and treatment of gastrointestinal injuries by regulating the secretion and motility of the gastrointestinal tract, and provides important directions for research on gastrointestinal hormones.

(i)Clinical Adjuvant Therapy: Protective Intervention for Gastrointestinal Tract Injuries

 

Adjuvant Treatment of Gastrointestinal Fistulas: Pancreatic fistulas, biliary fistulas, and enteric fistulas are common severe complications following abdominal trauma or abdominal surgery. These fistulas persistently leak digestive fluids, which contain corrosive substances such as gastric acid and pancreatic juice. These fluids continuously irritate the surrounding tissues, exacerbating tissue necrosis, infection, and impeding fistula healing. This drug reduces the overall secretion of gastric acid through multiple pathways, including direct inhibition of gastric parietal cell acid secretion and suppression of gastrin release. Simultaneously, it decreases the overall secretory load of gastrointestinal digestive fluids. The reduction in both the volume and acidity of digestive fluids significantly mitigates corrosion and inflammatory stimulation to the fistula tissues, controls local infection risks, and creates favorable local tissue conditions for spontaneous fistula healing or subsequent surgical repair. This makes secretin a vital adjunctive component in the comprehensive management of gastrointestinal fistulas.

Prevention of Stress-Induced Gastric Mucosal Injury: Under stress conditions such as severe trauma, extensive burns, major surgeries, or critical infections, sympathetic nervous system activation leads to reduced gastric mucosal blood flow and increased gastric acid secretion, making stress-induced gastric ulcers and mucosal erosions with bleeding highly likely. It can intervene proactively by inhibiting excessive gastric acid secretion during stress and delaying gastric emptying. This reduces the continuous irritation of the gastric mucosa by acidic chyme, enhances the mucosal defense capacity, and effectively lowers the risk of stress-induced gastric mucosal injuries.

(II)Research Applications: Gastrointestinal Hormone Regulatory Network and New Drug Development
The secretory and motor functions of the gastrointestinal tract are regulated by a complex network of various gastrointestinal hormones, with it playing a key role in this network. Researchers focus on studying the interactions and feedback regulatory mechanisms among hormones such as secretin, gastrin, and somatostatin. Gastrin is a core hormone that promotes gastric acid secretion and accelerates gastric emptying, while somatostatin is a broad-spectrum inhibitor of gastrointestinal secretion.

 

Secretin injection acts in an antagonistic and synergistic manner with these hormones to maintain the homeostasis of gastric acid secretion and gastric motility. By investigating this regulatory network, researchers can gain deeper insights into the pathogenesis of diseases such as gastric ulcers, functional dyspepsia, delayed gastric emptying, and gastrinomas, and elucidate the patterns of gastrointestinal hormone imbalances during disease progression. Furthermore, targeting secretin-related pathways enables the development of novel acid-suppressing drugs and gastrointestinal motility modulators. Compared to traditional acid-suppressing medications, drugs developed based on it can more precisely regulate the gastrointestinal hormone network, simultaneously inhibiting gastric acid secretion and modulating gastrointestinal motility. This holds promise for providing entirely new therapeutic strategies for disorders of gastric acid secretion and gastrointestinal motility dysfunction.

The two classic physiological effects of it injection:stimulating the pancreas to secrete alkaline pancreatic juice to neutralize gastric acid in the intestines and inhibiting gastric acid secretion while delaying gastric emptying, collectively establish a critical mechanism for maintaining acid-base balance and mucosal defense in the digestive tract.

At the clinical application level, leveraging the former effect, the drug stimulation test has become a core method for evaluating pancreatic exocrine function. It effectively aids in the early diagnosis and disease progression assessment of conditions such as chronic pancreatitis, pancreatic cancer, and cystic fibrosis. Furthermore, exogenous secretin intervention significantly improves digestive disorders in patients with severe pancreatic exocrine insufficiency, enhancing nutrient absorption efficiency.

Additionally, its role in inhibiting gastric acid secretion and regulating gastrointestinal motility plays an indispensable auxiliary and protective function in the repair of gastrointestinal fistulas and the prevention of gastric mucosal injuries under stress conditions. In the field of basic research, these two functions serve as key entry points for exploring pancreatic secretion regulation and gastrointestinal hormone signaling networks. They lay a solid foundation for deciphering the pathogenesis of gastrointestinal and pancreatic diseases and identifying novel drug targets.

With the continuous advancement of related research, the clinical application potential and scientific value of it are expected to be further uncovered, offering new possibilities for the prevention and treatment of gastrointestinal and pancreatic diseases.

• What are secretin?

This injection is used for the stimulation of pancreas secretions to help diagnose or find problems in the pancreas and to help identify the ampulla of Vater and accessory papilla during endoscopy. It is also used to help in the diagnosis of gastrinoma (tumor of the bowel or pancreas).

• How is secretin administered?

It is given to the patient by injection into a vein. After a certain amount of time, samples of fluid are taken from the small intestine through the tube and sent to a lab to test for a response.

• What organ does secretin target?

Secretin's primary target organ is the pancreas, stimulating it to release bicarbonate-rich fluid to neutralize stomach acid in the duodenum, but it also affects the liver, stomach, and kidneys, promoting bile, inhibiting acid, and regulating water balance, respectively, with receptors also found in the brain.

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