Earthworm Peptide

Earthworm peptide is a multifunctional bioactive substance that plays multiple roles in promoting health. Firstly, it can promote blood circulation and remove blood stasis, helping to alleviate problems caused by poor blood circulation and qi stagnation, such as reducing joint pain and increasing range of motion. Secondly, earthworm protein peptides are rich in high-quality protein, Kpeptide offers a variety of protein expression systems, enabling protein expression at different scales to meet client needs. Kpeptide's Earthworm peptide effectively accelerates metabolism and significantly improves metabolic abnormalities. Furthermore, earthworm peptides have shown potential for cough relief, particularly for coughs caused by bronchospasm.

Certificate of Analysis
Compound name	Earthworm Peptide
Grade	Pharmaceutical grade
CAS	N/A
Quantity	25g
Packaging standard	PE bag+Al foil bag
Manufacturer	Shaanxi BLOOM TECH Co., Ltd
Lot No.	202601090066
MFG	Jan 9th 2026
EXP	Jan 8th 2029
Structure	N/A
Item	Enterprise standard	Analysis result
Appearance	White or almost white powder	Conformed
Water content	≤5.0%	0.40%
Loss on drying	≤1.0%	0.21%
Heavy Metals	Pb≤0.5ppm	N.D.
	As≤0.5ppm	N.D.
	Hg≤0.5ppm	N.D.
	Cd≤0.5ppm	N.D.
Purity (HPLC)	≥99.0%	99.98%
Single impurity	<0.8%	0.42%
Total microbial count	≤750cfu/g	205
E. Coli	≤2MPN/g	N.D.
Salmonella	N.D.	N.D.
Ethanol (by GC)	≤5000ppm	520ppm
Storage	Store in a sealed, dark, and dry place below 2-8°C
N/A

Earthworm peptide, also known as medicinal earthworms, have a medicinal history of nearly two thousand years in China. They were first recorded in the "Shennong Bencao Jing" and were designated as "new resource foods". And the earthworm protein peptide, a small molecule active substance extracted from earthworm protein through modern biotechnology such as enzymatic hydrolysis and membrane separation, is entering the core stage of modern medicine and functional food with thunderous momentum. It is rich in free amino acids, highly unsaturated fatty acids, and various bioactive peptides, integrating more than ten pharmacological activities such as antipyretic sedation, cough and asthma relief, blood pressure lowering, antithrombotic, antioxidant, immune regulation, blood glucose lowering, anti-tumor, etc. It can be regarded as a model of perfect integration of traditional Chinese medicine and modern biotechnology.

Reduced fever and sedation: the "nemesis" of high fever and convulsion

The most classic medicinal value originates from the thousand year tradition of traditional Chinese medicine's "calming the nerves and calming the wind". Wang Lei, Deputy Chief Physician of the First Affiliated Hospital of Zhejiang University School of Medicine, clearly pointed out that it has the effect of reducing fever and calming, and can be used to improve high fever caused by various diseases, as well as to alleviate symptoms such as convulsions, in order to avoid triggering epilepsy.

Its antipyretic mechanism is to act on the temperature regulation center to achieve a cooling effect, while also having a sedative effect to alleviate neural excitability. For emergencies such as sudden wind shock, high fever, and dizziness in children, earthworm protein peptide can quickly calm the "internal wind" and is an indispensable auxiliary medication in pediatric clinical practice.

For epilepsy patients, the characteristic of relieving seizures is of great significance - it does not forcibly suppress nerves, but regulates nerve excitability from the root, reducing the risk of epileptic seizures.

Cough and asthma relief: the "guardian" of the respiratory system

The performance in respiratory system diseases can be considered outstanding. Multiple authoritative studies have unanimously confirmed that this substance can regulate bronchial smooth muscle tone, alleviate bronchial smooth muscle spasm, improve cough symptoms caused by bronchitis or asthma, and can assist in the treatment of diseases such as bronchitis, cough variant asthma, and asthmatic bronchitis. Its mechanism of action is clear: the active ingredients contained in it can directly relax bronchial smooth muscle, reduce airway hyperresponsiveness, and alleviate airway inflammation. For patients who have been struggling with cough for a long time, this naturally sourced anti asthmatic ingredient is milder and safer than chemically synthesized drugs, especially suitable for children and the elderly.

Diuretic and gonococcal: a "dredging agent" for the urinary system

Has significant diuretic and laxative effects. It can enhance renal excretion function and effectively alleviate urinary abnormalities caused by urinary tract infections, including symptoms such as frequent urination, urgency, and pain during urination. At the same time, it also has a good improvement effect on symptoms such as oliguria and edema. This characteristic makes it widely applicable in areas such as urinary system infections and urinary difficulties caused by prostate hyperplasia. Unlike chemical diuretics, Kpeptide diuretic effect is mild and long-lasting.

And it is not easy to cause electrolyte imbalance, making it an ideal adjuvant medication for patients with urinary system diseases.

Lowering blood pressure: Natural ACE inhibitory peptide, comparable in effect to Captopril

Lowering blood pressure is the most dazzling star application of earthworm peptide in the field of cardiovascular and cerebrovascular diseases. As early as 2013, Zhang Lan'e, Li Qinghua, Kang Bai and others from Weifang Medical College published a study in the journal "Natural Product Research and Development",

which confirmed that it contains 18 types of amino acids, among which leucine and glutamic acid have the highest content. It also contains 8 essential free amino acids for the human body and has significant angiotensin-converting enzyme (ACE) inhibitory activity.

In this study, the active protein of earthworm was purified by gel filtration chromatography. SDS-PAGE electrophoresis showed that its relative molecular weight was 1.4 × 10 ≮, 1.7 × 10 ∨, 3.1 × 10 ∨, 6.6 × 10 ∨. Its activity was confirmed by ACE inhibition experiment in vitro.

More importantly, animal experiments have shown that it can significantly reduce the blood pressure of spontaneously hypertensive rats (SHR), providing a reliable experimental basis for the development of drugs or health products for the prevention and treatment of hypertension from traditional Chinese medicine Dilong. Its antihypertensive mechanism lies in its ability to relax vascular smooth muscle cells, reduce peripheral resistance, and exert its antihypertensive effect by regulating vascular tension.

It can be used as an adjuvant therapy for patients with mild hypertension, with mild effects and much lower adverse reactions than synthetic antihypertensive drugs.

Antithrombotic formation: the "cleaner" of blood vessels

Containing earthworm kinase and fibrinolytic enzyme, it can directly dissolve fibrin formed by human thrombosis and has a strong thrombolytic effect.

Specifically, it can inhibit platelet aggregation and adhesion, reduce blood clotting, and thus prevent thrombosis.
This characteristic makes it an ideal adjuvant medication for high-risk populations of cardiovascular diseases, such as coronary heart disease and stroke patients. After taking it, it can soften blood vessels, dissolve blood clots, improve microcirculation, reduce blood viscosity, and has the unique advantage of bidirectional blood pressure regulation - it can both lower blood pressure and have a rebound effect when blood pressure is too low, which is difficult for synthetic drugs to achieve.

The latest research on the protein peptides of Lumbricus lumborum in 2026 further discovered that the weight average molecular weight of the anticoagulant active protein site in Kpeptide Lumbricus lumborum is 23-30 kDa, which is similar to the molecular weight of Lumbricus kinase. This lays a solid foundation for the in-depth study of anticoagulant substances in Lumbricus lumborum.

Antioxidant stress: the 'terminator' of free radicals

The antioxidant activity of earthworm protein peptides has been repeatedly validated by multiple modern studies. The study published by Zhang Yi, Zhou Feiyan, Wu Hui and others from South China University of Technology in Modern Food Technology (2023) identified multiple highly efficient antioxidant peptides from the gastrointestinal digestion products of earthworm protein using an in vitro simulated digestion model. 

This study used density functional theory (B3LYP/6-311G (d)) in quantum chemistry for structure-activity analysis, revealing the molecular mechanism of the active site: the active site of AFWYGLPCKL is located at N29-H108 on the Trp-3 indole group,

releasing active hydrogen to achieve antioxidant activity; The active site of GCFRYACGAFY is located on the phenolic hydroxyl group O122-H38 on Tyr, serving as a hydrogen donor to provide H38 for antioxidant activity; The active site of HLASGWY is located on Trp-6, with the indole group of tryptophan serving as a hydrogen donor. with the indole group of tryptophan serving as a hydrogen donor.

In addition, the DPPH clearance rate and ORAC value of the earthworm peptide hydrolysate pre hydrolyzed by alkaline protease were increased by 72.21% and 120.00% respectively after gastrointestinal digestion compared to direct digestion products, fully demonstrating that enzymatic pretreatment can significantly enhance the antioxidant activity of earthworm protein peptides.

7. Immune regulation: the overall command of the body's defense
It can stimulate macrophage activation, promote lymphocyte proliferation, enhance NK cell activity, increase immunoglobulin levels, thereby enhancing the body's resistance to external pathogens.

Clinical studies have shown that oral preparations have significant adjuvant therapeutic effects on immune dysfunction, recurrent respiratory infections, and leukopenia. They can increase peripheral white blood cells and improve bone marrow hematopoietic function.
The 18 amino acids it contains (including Glu, Leu, Pro, etc.) provide sufficient raw material support for the proliferation and differentiation of immune cells. The experimental study published by Tang Xiaoyun et al. in the Journal of Cell and Molecular Immunology (2004) also confirmed the immunopharmacological effects of earthworm peptides.

8. Hypoglycemia and Metabolic Regulation: The 'Repairer' of Islets
In terms of blood glucose regulation, it exhibits a triple mechanism: promoting the recovery of pancreatic islet function and reducing blood glucose; Improve the internal environment and reduce blood viscosity; Promote metabolism and improve metabolic abnormalities.
Research has shown that earthworm peptide can promote the repair of pancreatic beta cells, promote normal insulin secretion, activate dormant receptors, increase tissue sensitivity to insulin,

and restore normal circulation of glucose and lipid metabolism. Its characteristic of reducing blood viscosity also helps to improve the common microcirculation disorders in diabetes patients. 

Procurement Services

1.Our dedicated technical and sales team provides one-on-one professional consultation for all Kpeptide Earthworm Peptide procurement clients. We offer full transparent technical specifications including molecular weight distribution, active peptide content, lumbrokinase activity data, and third-party test reports, and can also provide customized formulation guidance based on your specific application scenarios (functional food, dietary supplement, raw material processing etc.). We will also clearly inform you of the product's storage requirements, transportation precautions and applicable regulatory compliance information before order confirmation.

2. Flexible Order & Customization Service
We support flexible order configurations covering small trial orders starting from 1kg, bulk industrial orders of 25kg and above, and large-scale 1000kg level customized production. For clients with special requirements on peptide purity, molecular weight range or solubility, our R&D team can provide targeted enzymatic hydrolysis process adjustment and product customization services, to make the final product fully match your production formula standards.

References:

[1] Zhang Lan'e, Li Qinghua, Kang Bai, etc Composition analysis of earthworm protein peptides and their effects on angiotensin-converting enzyme activity [J]. Natural Products Research and Development, 2013, 25:1740-1742, 1747

[2] Zhang Yi, Zhou Feiyan, Pan Leiman, He Ping, Zhang Yizhe, Yang Jinxi, Huang Ming, Wu Hui, Zhang Mengmeng Identification and structure-activity relationship of antioxidant peptides derived from earthworm protein [J]. Modern Food Technology, 2023, 39 (3): 164-173. DOI: 10.13982/j.mfst.1673-9078.2023

[3] Wang Lei (Deputy Chief Physician of the First Affiliated Hospital of Zhejiang University School of Medicine) What is the efficacy and function of earthworm protein peptide [EB/OL]. Baidu Health, May 15, 2026

[4] Tang Xiaoyun, Xu Jing, Geng Zaifu, etc Experimental Study on the Immunopharmacological Effects of Earthworm Peptides [J]. Journal of Cell and Molecular Immunology, 2004, 20 (2): 249-250

[5] Meng Shengxi, Huo Qingping The effect of earthworm and its active ingredients on neurological diseases [J]. Shandong Journal of Traditional Chinese Medicine, 2016, 35 (10): 933-936

[6] Chen Xuedong, Tian Daofa, Kill the Rainbow The effect of earthworm protein component III on vascular density and MMP-9 expression in nasopharyngeal carcinoma cell xenografts in nude mice [J]. Chinese Journal of Integrated Traditional Chinese and Western Medicine Otolaryngology, 2007, 15 (5): 326-328

[7] Guo Jian, Gao Fuyun, Suo Yaoying, etc The effect of active protein from earthworm on immune hematopoietic function and its anti-tumor effect [J]. Chinese Journal of Traditional Chinese Medicine, 2009, 24 (5): 670-672

[8] Hu Liangjun Analysis of Polypeptides and Separation Analysis of Anticoagulant Proteins in Lumbricus [D]. Nanjing University of Traditional Chinese Medicine, 2026

[9] Li Chengde, Kang Bai, Mao Shu, etc The effect of earthworm antihypertensive protein on the antihypertensive effect and mechanism in spontaneously hypertensive rats [J]. Chinese Journal of Traditional Chinese Medicine, 2008, 23:450-452

[10] Sheng Aizhen, Xu Zhongbao Laboratory efficacy of multi center, double-blind, placebo-controlled treatment with earthworm kinase in patients with ischemic cerebrovascular disease [J]. Chinese Journal of New Drugs, 2008, 448 (3): 292-297

[11] Tracing back to the source and exploring new paths, combining Chinese and Western medicine to protect health | Composition analysis of earthworm protein peptides and their effects on angiotensin-converting enzyme activity [EB/OL]. WeChat public platform, October 20, 2023

[12] Research progress on the peptide components of earthworm protein [J]. Tianjin Journal of Traditional Chinese Medicine, 2023 (7)

[13] The efficacy and function of earthworm protein peptide [EB/OL]. 39 Health Net, May 12, 2025

[14] What are the functions and effects of earthworm protein peptides [EB/OL]. Medical Credit Information Platform, May 3, 2026

[15] What is the efficacy and function of earthworm protein peptide [EB/OL]. Popular Health Network, September 18, 2025

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