Acetyl hexapeptide-38 injection is a novel bioactive peptide injectable formulation targeting soft tissue remodeling with the CAS number 1400634-44-7. It is a specific functional hexapeptide compound screened out via high-throughput peptide library screening. Unlike conventional anti-aging peptides that only exert a single collagen-repairing effect, its core mechanism of action lies in activating the human PGC-1α signaling pathway to bidirectionally regulate dermal collagen synthesis and benign proliferation of subcutaneous fat. While thickening the dermal layer and firming the skin, it enables targeted and uniform filling of adipose tissue, eliminating the uneven surface and stiff artificial appearance caused by traditional filling materials. As a differentiated biologic agent for medical aesthetic contouring, it features core strengths including high biocompatibility, low rejection risk, and mild yet long-lasting efficacy, catering to demands for refined, natural body contouring.
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Acetyl Hexapeptide-38 COA
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| Certificate of Analysis | ||
| Compound name | Acetyl Hexapeptide-38 | |
| Grade | Pharmaceutical grade | |
| CAS No. | 1400634-44-7 | |
| Quantity | 17g | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090056 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure | N/A | |
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.41% |
| Loss on drying | ≤1.0% | 0.35% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.98% |
| Single impurity | <0.8% | 0.24% |
| Total microbial count | ≤750cfu/g | 400 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 550ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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Application Scenarios for Body Contouring
Refined Gentle Contouring of the Torso
Torso contouring represents the most core blue-ocean application scenario of acetyl hexapeptide-38 injection. It mainly addresses soft tissue deficiency, body sagging and flat body contours on the chest, waist, abdomen, back and other torso areas, meeting the general public's regular demand for body shape optimization.In breast contouring, distinct from exaggerated shaping via breast implants and the high failure rate of conventional fat grafting, this injection is suitable for mild-to-moderate breast issues such as flat breasts, shrunken breast contours, postnatal breast atrophy and sagging, and bilateral breast asymmetry. Administered via targeted fixed-point injection into subcutaneous breast soft tissue, it activates benign proliferation of local adipocytes to evenly increase soft tissue thickness of the breasts.
Meanwhile, it stimulates collagen regeneration in breast skin and tightens loose epidermal tissue.It boosts breast fullness while preserving the natural, soft native texture of breasts, avoiding the stiff foreign body sensation of implants, making it ideal for consumers who pursue natural body shapes and reject overdone contouring results.For problems including loose back skin, flat back contours, sunken soft tissue on the waist flanks and a gaunt, lifeless physique, the product delivers refined body optimization. Prolonged sedentary lifestyles and irregular schedules lead to uneven subcutaneous fat distribution and collagen loss on the waist and back, resulting in sagging skin and blurred body lines, which are hard to improve through non-invasive conventional contouring methods.
Administered via micro fixed-point injections, this formulation modulates waist and back fat distribution, fills local soft tissue depressions, thickens the dermis and firms lax skin to reshape smooth waist-back lines, ameliorating gaunt and flabby physiques and creating a tight, well-proportioned torso silhouette.Compared with fitness contouring (which requires long cycles, yields slow results and cannot precisely correct local depressions) and highly invasive surgical contouring, this injectable solution is convenient, efficient and carries minimal risks.
Limb Body Shape Optimization & Local Filling
Refined limb contouring is an untapped niche segment in the current medical aesthetics market and another core blue-ocean application of the product. Traditional aesthetic contouring treatments mostly focus on the face and torso, while safe, non-invasive solutions have long been lacking for sagging, depressions and flat contours on arms, legs, shoulders and necks.
Most consumers suffer from aesthetic flaws such as sagging bat wings on upper arms, gaunt upper arms, thin calf lines, shoulder-neck depressions without defined right-angle shoulders, and soft tissue depressions around joints. These issues do not require drastic reshaping; subtle soft tissue filling and firming can dramatically enhance overall body aesthetics.Acetyl hexapeptide-38 injection is tailored to meet all types of refined limb contouring demands. For upper limb shaping, it targets sagging upper arm skin, thin soft tissue and shoulder-neck connecting depressions. Via layered micro-injections, it promotes uniform local fat proliferation and collagen tightening, fills shoulder-neck hollows, optimizes shoulder-arm lines to create naturally smooth right-angle shoulders and toned upper arms, visually correcting a hunched posture and gaunt frame.
For lower limb contouring, it addresses thin calves, joint depressions and disjointed leg lines by precisely filling local soft tissue defects and evening out leg contours while tightening lax leg skin. It avoids stiff muscles and overly thin legs triggered by conventional leg-slimming treatments to deliver soft, natural lower body reshaping.
Regular Light Medical Aesthetic Anti-Aging & Contouring Maintenance
As light medical aesthetics consumption becomes mainstream, public contouring demands have shifted from "problem correction" to "daily maintenance and anti-aging stabilization", making anti-aging body soft tissue contouring an emerging blue-ocean demand.
Conventional anti-aging products predominantly target the face, with an extreme shortage of body-focused anti-aging contouring maintenance solutions.The product serves as a routine body anti-aging maintenance formulation for regular body silhouette stabilization and delayed soft tissue aging. Periodic micro-injections sustain activation of subcutaneous tissue repair and regeneration mechanisms, maintaining a balanced state of fat and collagen to slow skin sagging, soft tissue atrophy and contour aging, and preserve tight, smooth body outlines long-term.
Lip Care Efficacy
Targeted Activation of Lip Fat Regeneration to Plump Basal Contours
Relying on its exclusive PGC-1α signaling pathway activation mechanism, the product realizes targeted conditioning and remodeling of lip soft tissue. It breaks the limitation of ordinary lip care products that only provide superficial moisturization, improving the native lip state from the dermis and subcutaneous fat layer.The lip skin is thin and delicate with minimal subcutaneous fat, rendering it the most prone to thinning and aging on the face. Aging, repeated lip movement stretching and external environmental irritation reduce the activity of lip preadipocytes and lipid accumulation, causing flat lip tubercles, blurred cupid's bows and thin lip rims.
This peptide injection precisely upregulates PGC-1α protein expression in lip subcutaneous tissue, accelerates differentiation and maturation of preadipocytes, and promotes ordered adipocyte proliferation and even lipid deposition.It mildly increases the thickness of lip subcutaneous soft tissue to plump the basal lip contour fundamentally, instead of relying on mechanical filling with foreign substances. Its contouring and conditioning effects naturally conform to native lip morphology without stiff foreign body sensations. In addition, its precise targeting property prevents excessive hyperplasia of perioral tissue and ensures delicate lip shaping results.
Autologous Lip Plumping for Refined Lip Morphology Optimization
Hyaluronic acid lip fillers are prone to side effects including swollen artificial-looking lips, translucent stiffness and short duration of efficacy. In contrast, acetyl hexapeptide-38 injection features "regenerative lip plumping" and stands as a premium solution for refined lip contour care. For congenital thin lips, flat lip shapes, indistinct lip tubercles and bilateral lip asymmetry, fixed-point micro-injections into lips accurately fill soft tissue deficiencies, evenly boost lip fullness, sculpt distinct cupid's bows and three-dimensional lip tubercles, and refine delicate native lip styles such as M-shaped lips and smiling lips.
Its mechanism relies on activating autologous tissue regeneration; post-treatment lips match native lips fully in softness and elasticity with authentic, natural texture, free from the hardness, swelling and translucency characteristic of synthetic fillers. It also precisely corrects blurred lip rims and sunken, shriveled lips, carving crisp, clean lip outlines and mitigating the visual flaws of drooping mouth corners and saggy, loose lips, fitting regular demands for subtle lip maintenance.
Long-Term Nourishing Repair to Improve Lip Skin Conditions
Breaking the limitation of traditional lip care products that only deliver superficial hydration, the product delivers deep repair and long-lasting nourishment.
It addresses common lip skin issues including seasonal chapping, residual roughness from recurrent cheilitis, persistent peeling, dull yellow lip tone and purplish-black lips. It deeply repairs the skin barrier to lock lip moisture, fundamentally eliminating dryness, flaking and recurrent chapping. Meanwhile, it boosts lip microcirculation, accelerates metabolism of accumulated dull pigment, brightens and evens lip tone, fades perioral dullness and dark lip lines, and restores translucent, pink native lip color.Furthermore, its highly biocompatible formula is mild and non-irritating, free of hormones and sensitizing ingredients. It repairs lip damage caused by long-term lipstick wear, makeup removal irritation, ultraviolet radiation and dry environments, continuously rehabilitates fragile lip texture and elevates lip skin tolerance, achieving integrated contouring and skin conditioning effects.
Synthetic Process
Currently, the mainstream industrial synthesis method for Acetyl Hexapeptide-38 is Fmoc Solid-Phase Peptide Synthesis (Fmoc-SPPS), a mature process compatible with large-scale mass production and high-purity output. The overall workflow is standardized and highly controllable, delivering finished products with stable purity above 98% that meet raw material standards for medical aesthetic injections.
The synthesis uses Fmoc-protected MHBA resin as the solid-phase carrier. First, the resin is swelled and cleaned in DCM and DMF solutions for carrier pretreatment.
Three core cyclic reactions-Fmoc deprotection, amino acid coupling and solvent washing-are then performed to sequentially attach six target amino acids: Serine, Valine, Valine, Valine, Arginine and Threonine, gradually assembling the complete peptide chain.
Each round of amino acid coupling forms peptide bonds with the aid of activators, with thorough removal of excess reagents and byproducts to avoid impurity residues.After full peptide chain assembly, a cleavage solution separates the intact peptide chain from the resin carrier while removing all side-chain protecting groups.
Acetylation modification is subsequently conducted to obtain crude target peptide. Final high-purity Acetyl Hexapeptide-38 powder is yielded via high-performance liquid chromatography (HPLC) purification, vacuum drying and sterile filtration, ready for direct formulation of injectables.
This process boasts simple operation and high batch-to-batch stability. Domestic localized technology has realized large-scale, low-cost mass production, complying with manufacturing standards for medical aesthetic formulations.
References
- MedChemExpress. Acetyl hexapeptide-38[EB/OL]. May 28, 2026.
- Benchchem. An In-depth Technical Guide to the Discovery and Characterization of Acetyl Hexapeptide-38[EB/OL]. June 4, 2026.
- Zhuanpeptide Biotechnology. Technical Manual of 1400634-44-7 Acetyl Hexapeptide-38[EB/OL]. March 26, 2026.
- ChemicalBook. Properties, Applications and Production Processes of Acetyl Hexapeptide-38[EB/OL]. April 16, 2026.
- 2025 China Acetyl Hexapeptide-38 Industry Market Prospect Forecast and Investment Value Assessment Report[R]. Docin, November 2025.
FAQ
What is acetyl hexapeptide 38 used for?
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Acetyl hexapeptide-38 can be used in the field of cosmetic medicine to repair congenital soft tissue defects, reduce tear grooves and nasolabial folds, eliminate postoperative scars, and conduct micro-plastic surgery of skin tissue.
What are the side effects of acetyl hexapeptide 38?
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Acetyl hexapeptide 38 is safe to use and has no known side effects. However, it is essential to note that the product should not be ingested, and care should be taken to avoid contact with the eyes.
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