Ganirelix 0.25 Mg

Ganirelix 0.25 Mg
Details:
1.General Specification(in stock)
(1)API(Pure powder)
(1)Injection
2.Customization:
We will negotiate individually, OEM/ODM, No brand, for secience researching only.
Internal Code: KP-3-82/001
Ganirelix CAS 129311-55-3
Ganirelix Acetate CAS 123246-29-7
Molecular formula: C80H113ClN18O13
HS Code: 3504009000
Molecular weight: 1570.34
EINECS number: N/A
MDL No.: MFCD00869671
Main market: USA, Australia, Brazil, Japan, Germany, Indonesia, UK, New Zealand , Canada etc.
Analysis: HPLC, LC-MS, HNMR
Technology support: R&D Dept.-3
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Description
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Ganirelix 0.25 mg, as a type of gonadotropin-releasing hormone antagonist, occupies an important position in the modern reproductive medicine system. Its core applications focus on the precise regulation of controlled ovarian stimulation processes in assisted reproductive technology, and it also has wide application value in endocrine regulation research and related disease models. Compared with traditional regulatory strategies, this drug can achieve direct inhibition of the hypothalamic pituitary gonadal axis in a rapid and reversible manner, thereby providing a higher degree of temporal controllability and safety in clinical pathways.

 
Our Products Description
 
Ganirelix injection | Shaanxi BLOOM Tech Co., Ltd
Ganirelix | Shaanxi BLOOM Tech Co., Ltd
Ganirelix Acetate injection | Shaanxi BLOOM Tech Co., Ltd

Ganirelix Price List | Shaanxi BLOOM Tech Co., Ltd

Ganirelix Price List | Shaanxi BLOOM Tech Co., Ltd

 Method of Analysis | Shaanxi BLOOM Tech Co., Ltd

COA

  Shaanxi BLOOM Tech Co., Ltd
Certificate of Analysis
Compound name Ganirelix / Ganirelix Acetate
Grade Pharmaceutical grade
CAS No. 129311-55-3 / 123246-29-7
Quantity 80g
Packaging standard PE bag+Al foil bag
Manufacturer Shaanxi BLOOM TECH Co., Ltd
Lot No. 202601090078
MFG Jan 9th 2026
EXP Jan 8th 2029
Structure

Ganirelix structure | Shaanxi BLOOM Tech Co., Ltd

Item Enterprise standard Analysis result
Appearance White or almost white powder Conformed
Water content ≤5.0% 0.54%
Loss on drying ≤1.0% 0.42%
Heavy Metals Pb≤0.5ppm N.D.
As≤0.5ppm N.D.
Hg≤0.5ppm N.D.
Cd≤0.5ppm N.D.
Purity (HPLC) ≥99.0% 99.98%
Single impurity <0.8% 0.52%
Total microbial count ≤750cfu/g 95
E. Coli ≤2MPN/g N.D.
Salmonella N.D. N.D.
Ethanol (by GC) ≤5000ppm 500ppm
Storage

Store in a sealed, dark, and dry place below -20°C

Ganirelix NMR | Shaanxi BLOOM Tech Co., Ltd

 Shaanxi BLOOM Tech Co., Ltd

Chemical Formula C80H112ClN17O13
Exact Mass 1554
Molecular Weight 1555
m/z 1554 (100.0%), 1555 (86.5%), 1556 (37.0%), 1556 (32.0%), 1557 (27.7%), 1558 (11.8%), 1557 (10.4%), 1555 (6.3%), 1556 (5.4%), 1559 (3.1%), 1556 (2.7%), 1557 (2.3%), 1557 (2.3%), 1558 (2.2%), 1557 (2.0%), 1558 (1.7%), 1556 (1.1%)
Elemental Analysis C, 61.78; H, 7.26; Cl, 2.28; N, 15.31; O, 13.37

 Usage | Shaanxi BLOOM Tech Co., Ltd

Ganirelix uses | Shaanxi BLOOM Tech Co., Ltd

The core regulatory use of controlled ovarian stimulation in assisted reproductive technology

In the assisted reproductive technology system, the application of ganirelix 0.25 mg mainly focuses on the controlled ovarian stimulation stage, and it is included as a key regulatory tool in the standard treatment pathway to maintain the stability of the endocrine environment during gonadotropin stimulation. In in vitro fertilization and related technologies, this drug is used to suppress endogenous hormone fluctuations, allowing follicle development to proceed at a predetermined pace, thereby providing controllable conditions for subsequent egg retrieval operations. Its use is not only reflected in the regulation of single hormone levels, but also in the reshaping of the rhythm of the entire ovarian stimulation process, enabling the treatment pathway to operate in a highly predictable state.

In practical clinical applications, it is usually used in combination with drugs such as follicle stimulating hormone to form a complete stimulation and inhibition system through the synergistic effect of multiple factors. In this system, its function runs through the middle and late stages of follicular development, by continuously inhibiting inappropriate endogenous signals, allowing multiple follicles to maintain a relatively synchronized developmental state, thereby improving the coordination and success rate of the overall treatment process.

Ganirelix applicaiton | Shaanxi BLOOM Tech Co., Ltd
Ganirelix premature | Shaanxi BLOOM Tech Co., Ltd

Accurate control of preventing premature luteinizing hormone peak

The early appearance of luteinizing hormone peak in natural and ovulation induction cycles is an important factor leading to uncontrollable ovulation time. It is widely used in this clinical problem to precisely control hormone fluctuations, by inhibiting related secretion processes to maintain luteinizing hormone levels within a controllable range, thereby avoiding ovulation events from occurring at unexpected times.

This use has core significance in assisted reproductive technology, as deviations in ovulation timing will directly affect the timing and quality of egg retrieval. In different stimulation schemes, it is used to dynamically adjust the treatment rhythm, so that the clinical operation time can be accurately matched with the follicular maturation status, thereby forming a highly coordinated time control system throughout the entire treatment process.

Application of individualized treatment in patients with polycystic ovary syndrome

In patients with polycystic ovary syndrome, due to the complex endocrine environment and sensitivity to stimuli, hormone fluctuations and the risk of complications are more likely to occur during the treatment process. In this context, it is used in personalized treatment plans to enhance the controllability of the treatment process. In related research and practice, this drug has been used to regulate hormone changes during ovarian stimulation, making the treatment pathway smoother.

In addition, in this type of patient, its use is also reflected in optimizing the synchronization of follicular development, thereby reducing the occurrence of abnormal ovulation events and supporting treatment safety management to a certain extent. By intervening at critical time points, it is possible to maintain a relatively stable regulatory state in a complex endocrine environment.

Ganirelix patients | Shaanxi BLOOM Tech Co., Ltd
Ganirelix risk | Shaanxi BLOOM Tech Co., Ltd

Application of risk control in ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome is one of the important potential risks in assisted reproductive processes, and its occurrence is closely related to fluctuations in hormone levels. Ganirelix is used in the relevant risk control system to regulate the hormone environment and maintain the stimulation intensity within a safe range during the treatment process. In clinical pathway design, the drug is used to construct a milder and more controllable stimulation regimen, thereby reducing the probability of adverse events.

In high-risk patient populations, its use is particularly prominent, as it suppresses endogenous signals to make ovarian responses more predictable, thereby providing a more stable basis for clinical decision-making.

Discovering History

Ganirelix's Development History 

 
In 1950s to 1970s

At this stage of basic theory, ganirelix 0.25 mgdevelopment can be traced back to the study of the regulatory mechanism of the hypothalamic pituitary gonadal axis.

 
In the mid-20th century

The scientific community gradually recognized that the hypothalamus regulates pituitary function by secreting gonadotropin-releasing hormone (GnRH).

 
In 1971

Andrew V. Schally and Roger Guillemin successfully isolated and identified the structure of GnRH, laying the foundation for the subsequent development of GnRH analogs. This achievement later won the Nobel Prize in Physiology or Medicine, marking the entry of reproductive endocrine research into the molecular level.

 
In 1970s–1980s

After the structure of GnRH was clarified, the research focus shifted to developing its analogues to achieve artificial regulation of the reproductive endocrine system. The development of highly selective and low side effect GnRH antagonists has become a research focus, which directly promotes its birth.

 
In the early 1990s

In this era, with the development of peptide drug design technology, researchers have significantly improved the pharmacological properties of antagonists through amino acid modification.

 

Considered as one of the representative drugs of the third generation GnRH antagonists, its emergence marks the transition of GnRH antagonists from the experimental stage to the clinical application stage.

 
Mid to late 1990s

After the development is completed, it enters the clinical research stage of the system, mainly focusing on the field of assisted reproductive technology.

 
Around 2000

Anirelix officially received regulatory approval for assisted reproductive therapy, marking its entry into clinical practice and rapidly becoming an important component of GnRH antagonist regimens.

 

Its approval agencies include:
U.S. Food and Drug Administration(FDA)
European Medicines Agency(EMA)

 
In 2000-2010s

After entering clinical application, it was gradually included in the standard assisted reproductive treatment plan and promoted the development of the "antagonist regimen". During this period, Ganirelix gradually transformed from a "new drug" to a "standard tool drug".

 
From the 2010s to the present

In recent years, with the deepening of endocrine and molecular biology research, further in-depth studies have been conducted on endocrine regulation mechanisms, disease model construction, pharmacological research tools, and the refinement of reproductive medicine.

 
In 2020s

At present, it has become one of the widely used GnRH antagonists worldwide, and its development has entered a mature stage

 

The development history of Ganirelix can be summarized as the following timeline:
Basic Discovery (1970s) → Analogous Exploration (1980s) → Drug Development (1990s) → Clinical Validation (late 1990s) → Approval for Market (around 2000) → Clinical Optimization (2000-2010s) → Mechanism Deepening and Expansion (2010s present)
Ganirelix 0.25 mg development reflects the typical path of modern endocrine drugs from basic scientific discovery to precise clinical application, and also marks the maturity and improvement of GnRH antagonists in reproductive medicine.

 

References

 

1. European Medicines Agency. Ganirelix product information

2. U.S. Food and Drug Administration. Ganirelix acetate approval documents

3. ClinicalTrials.gov

4. Human Reproduction

5. Fertility and Sterility

6. The Journal of Clinical Endocrinology & Metabolism

7. Goodman & Gilman's The Pharmacological Basis of Therapeutics

 

FAQ

What does ganirelix do during IVF?

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It is a gonadotropin-releasing hormone (GnRH) antagonist used in IVF to prevent a premature LH surge, which stops the body from releasing eggs (ovulating) too early. By inhibiting this surge, it allows follicles to mature properly during controlled ovarian hyperstimulation, ensuring eggs are available for retrieval, usually starting around day 5-6 of stimulation.

Are ganirelix and Gonal F the same thing?

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Ganirelix Acetate - New Era Pharmacy - Portland, ORGonal-F and Ganirelix serve opposite, essential roles in IVF stimulation. Gonal-F (follicle-stimulating hormone) is used to stimulate ovaries to grow multiple follicles, typically for 8–12 days. Ganirelix is an antagonist started midway through stimulation to prevent early, premature ovulation of those follicles. They are not interchangeable.

Does ganirelix cause weight gain?

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Ganirelix Acetate Injection may cause serious side effects, including: Rapid weight gain or bloating. Severe or ongoing nausea, vomiting, diarrhea.

At what follicle size do you start ganirelix?

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Ganirelix (0.25 μg) was added when the lead follicle was ≥14 mm. Although the target was 14 mm, many patients had larger sized follicles when ganirelix was started. This occurred when the initial ultrasound was performed after the lead follicle had reached 14 mm.

Where is best to inject Ganirelix?

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Best place on stomach for menopur and gonal f injection : r/IVFThe best place to inject Ganirelix is subcutaneously into the fatty tissue of the lower abdomen, about 1–2 inches away from the belly button, or the upper/outer thigh. Rotating injection sites daily (e.g., clockwise around the navel) is recommended to minimize skin reactions, bruising, or tenderness.

 

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