Bovine spleen peptide is a bioactive peptide extracted from bovine spleen, mainly composed of small molecule peptides, amino acids, and trace elements. It has potential effects such as immune regulation, antioxidant, and anti fatigue, and is currently being studied in the fields of health food, pharmaceutical excipients, and sports nutrition. It is a small molecule peptide substance isolated from bovine spleen tissue through enzymatic hydrolysis or biological fermentation technology. The molecular weight is usually below 1000 daltons and is easily absorbed by the human body. The raw material, cow spleen, is a byproduct of slaughter, which achieves efficient utilization of resources through processing.
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Bovine Spleen Peptide COA
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| Certificate of Analysis | ||
| Compound name | Bovine Spleen Peptide | |
| Grade | Pharmaceutical grade | |
| Quantity | 55g | |
| CAS | N/A | |
| Packaging standard | PE bag+Al foil bag | |
| Manufacturer | Shaanxi BLOOM TECH Co., Ltd | |
| Lot No. | 202601090066 | |
| MFG | Jan 9th 2026 | |
| EXP | Jan 8th 2029 | |
| Structure | N\A | |
| Item | Enterprise standard | Analysis result |
| Appearance | White or almost white powder | Conformed |
| Water content | ≤5.0% | 0.17% |
| Loss on drying | ≤1.0% | 0.59% |
| Heavy Metals | Pb≤0.5ppm | N.D. |
| As≤0.5ppm | N.D. | |
| Hg≤0.5ppm | N.D. | |
| Cd≤0.5ppm | N.D. | |
| Purity (HPLC) | ≥99.0% | 99.89% |
| Single impurity | <0.8% | 0.36% |
| Total microbial count | ≤750cfu/g | 510 |
| E. Coli | ≤2MPN/g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (by GC) | ≤5000ppm | 458ppm |
| Storage | Store in a sealed, dark, and dry place below 2-8°C | |
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Bovine spleen peptide, a small molecule bioactive peptide extracted from the spleen of healthy and fresh cattle or buffalo, is prepared by crushing, sterilization, biological enzymolysis, enzyme killing, purification, concentration, centrifugal spray drying and other precision processes, with an average molecular weight of less than 500 daltons, and can be directly absorbed and utilized by the human body without digestion or slight digestion. It is rich in various bioactive ingredients such as peptides, single peptides, free amino acids, immunoglobulin, thymosin, etc., making it a concentrated "treasure trove of immunity".
1. Immune regulation: the first steel wall to strengthen the human body's defense
The most core and widely recognized efficacy is undoubtedly its outstanding immune regulatory ability. This is not groundless, but supported by solid experimental and clinical data.
1.1. Activate T cells and B cells to comprehensively enhance immune response
Rich in immune active factors, it can stimulate T lymphocyte proliferation and activation, promote lymphocyte maturation, and enhance the antibody response ability of B cells. Research has shown that it can promote spleen proliferation in tumor bearing mice, further activate the immune system, stimulate immune active cells including T lymphocytes and B lymphocytes in the body, and promote the recovery of the body's immune function. T cells in the human body are an important component of immune function, and their levels decrease with age.
Supplementing with bovine spleen can significantly promote T cells to maintain a good immune response and defense mechanism, thereby reducing the occurrence of diseases.
1.2. Enhance the phagocytic ability of macrophages
It can significantly enhance the phagocytic ability of macrophages and improve the non-specific immune function of the body. It has a clear improvement effect on immune dysfunction symptoms such as recurrent respiratory infections and chronic fatigue syndrome.
1.3. Inhibit humoral immunity and treat autoimmune diseases

The small molecule peptide KZ-36 (composed of 14 amino acids with a molecular weight<2000Da) derived from bovine spleen showed a significantly lower half hemolysis value in serum hemolysin formation experiments compared to physiological saline, similar to cyclosporine A, indicating its strong ability to inhibit humoral immune responses. Animal experiments have confirmed that KZ-36 has significant therapeutic effects on Masugi nephritis (an autoimmune glomerulonephritis) in rats: after 2 weeks of administration, the 24-hour urinary protein excretion was significantly reduced, and the blood creatinine (Cr) level decreased from 265 ± 212 μ mol/L in the model group to 86 ± 13 μ mol/L (P<0.01). The renal pathological changes were mild, and some indicators were even better than hydrocortisone. This discovery opens a new window for the application of bovine spleen peptides in the field of autoimmune diseases.
2. Strengthening the spleen and stimulating appetite: the golden regulator that reshapes the digestive system
The efficacy in regulating the spleen and stomach is another core selling point, combining traditional medical wisdom with modern scientific verification.
2.1. Repair spleen and stomach cells, restore transport function
The proportion and types of amino acids contained in it enable its molecules to have the activity of repairing spleen and stomach cells and regulating spleen and stomach function. The Dictionary of Traditional Chinese Medicine clearly records that the cow spleen itself is helpful in improving digestive disorders and spleen and stomach problems, and has the effect of invigorating the spleen and stimulating appetite. With a small molecular weight, it can be directly absorbed by the body, reducing the burden on the gastrointestinal tract and regulating the activity of the spleen and stomach, achieving the goal of strengthening the spleen and nourishing the stomach.


2.2. Promote digestion and absorption, improve appetite
It contains various digestive enzymes and rich dietary fiber, which helps to break down and absorb food, promote gastrointestinal peristalsis, improve gastrointestinal digestion and absorption capacity, and effectively alleviate discomfort symptoms such as indigestion, loss of appetite, and abdominal distension. Small molecule peptides can alter the permeability of biological membranes, achieving effective absorption of nutrients and excretion of toxins.
2.3. Wide prospects for children's applications
For children who do not like to eat, eat too much without gaining weight, suffer from constipation due to overeating, and have difficulty sleeping, it can be called the "secret weapon of growth". Most of the bovine spleen peptide products on the market are recommended for use by those over 3 years old, while some products are labeled as ready to consume after 6 months or 1 year old.
Please follow medical advice for specific instructions. Parents have reported that after using it for a month, their child's appetite has significantly increased, illness has decreased, and digestion has improved.
3. Anti fatigue: Injecting long-lasting energy into the body
Its anti fatigue effect makes it an ideal partner for athletes and high-intensity workers.
3.1. Regulate energy metabolism and accelerate lactate clearance
By regulating the activity of enzymes related to energy metabolism, lactate clearance can be accelerated and the occurrence of exercise-induced fatigue can be delayed. Athletes and manual laborers can improve their endurance performance after taking it.
3.2. Relieve both physical and mental fatigue
Cow spleen peptide helps alleviate physical and mental fatigue by regulating energy metabolism.


And sub-health individuals can see accelerated physical recovery after use. Its anti fatigue mechanism lies in regulating muscle nutrient metabolism, increasing the nutrient supply to muscle cells, improving muscle endurance and strength, and reducing fatigue.
4. Antioxidant and anti-aging: the youthful code that protects cells
4.1. Eliminate free radicals and alleviate oxidative stress
Glutathione peroxidase and superoxide dismutase (SOD) can effectively eliminate free radicals and alleviate oxidative stress damage. Suitable for people who stay up late for a long time and are exposed to high oxidative stress such as ionizing radiation.
4.2. Delaying cellular aging
The small molecule peptides can clear free radicals and delay the process of cellular aging. It is recommended to use it in conjunction with vitamin C, and it can be paired with antioxidant foods such as citrus fruits and dark vegetables in daily life.
5. Detoxification and Liver Protection: The Loyal Defender of the Liver
5.1. Accelerate alcohol breakdown metabolism
It contains various cytokines that can accelerate the breakdown and metabolism of alcohol, allowing it to be excreted from the body as soon as possible, alleviating symptoms of drunkenness, and reducing the stimulation and damage of alcohol to the liver.
5.2. Promote liver cell regeneration and repair
The unique hepatocyte growth factor can promote liver cell repair, reduce transaminase levels, and have a repairing effect on alcoholic liver injury and drug-induced liver injury. It is often used as an adjuvant therapy for liver disease. Individuals with abnormal liver function should use it under the guidance of a doctor and avoid taking it together with hepatotoxic drugs.


6. Promoting hematopoiesis: a powerful booster for the blood system
It can stimulate the proliferation and differentiation of bone marrow hematopoietic stem cells, increase the production of red blood cells, white blood cells, and platelets, and promote the renewal and repair of blood tissue. The erythropoietin analogs it contains have an improving effect on anemia and post chemotherapy blood cell reduction. It has a certain therapeutic effect on blood system diseases such as aplastic anemia. Blood routine should be monitored before use, and it is contraindicated for patients with severe blood disorders.
7. Beauty and skincare: the way to rejuvenate from the inside out
By promoting the synthesis of collagen and inhibiting its degradation, it helps maintain the elasticity and radiance of the skin, reduce the formation of wrinkles and pigmentation, improve skin quality, and delay the aging process of the skin. Its antioxidant capacity also provides an additional boost to its beauty benefits.
8. Improving Sleep: A Natural Solution for Enjoying Deep Sleep
It contains tryptophan, which can regulate the brain nerves, improve sleep quality, and alleviate symptoms such as insomnia and dreams. Combining regular sleep and moderate exercise yields better results.
9. Tumor adjuvant therapy:
As an immune modulator, it can be used as an adjuvant therapy for tumors to help improve the quality of life of patients. Research has shown that bovine spleen peptide has an inhibitory effect on tumor growth in mice with liver cancer, promotes spleen proliferation in tumor bearing mice, and activates the immune system. But it must be emphasized that the inhibitory effect on tumors is limited and cannot replace major treatment methods such as surgery, radiotherapy, and chemotherapy. Patients with splenic hyperfunction should use it with caution.

References
[1] Dr. Bohe What are the functions of bovine spleen peptide [EB/OL]. (2024-09-30) https://www.bohe.cn/article/view/5ude6hadkrkaim5.html
[2] Dr. Bohe The function and efficacy of bovine spleen peptide [EB/OL]. (2022-08-17) https://www.bohe.cn/article/view/at45id779kpb8z2.html
[3] Zhang Lei, Chen Xiaojuan, Jin Aiqiong The therapeutic effect of peptides extracted from bovine spleen on Masugi nephritis in rats [J]. Chinese Herbal Medicine, 2004, (06): 423-425
[4] 39 Health Network What is bovine spleen peptide made of [EB/OL]. (2026-05-10) https://wapask-mip.39.net/bdar/_0znux5.html
[5] Medical Alliance Media The function and efficacy of bovine spleen peptide [EB/OL]. (2024-03-29) http://www.yilianmeiti.com/article/2088968.html
[6] Dr. Bohe The function and efficacy of bovine spleen peptide [EB/OL]. (2026-02-13) https://article.fh21.com.cn/view/585037.html
[7] WeChat public platform Why is bovine spleen peptide super bovine [EB/OL]. (March 27, 2023) https://mp.weixin.qq.com
[8] WeChat public platform Nutritional Science Popularization: What is Bovine Spleen Peptide [EB/OL]. (2024-04-03) https://mp.weixin.qq.com
[9] Dr. Bohe The function and efficacy of bovine spleen peptide [EB/OL]. (2026-03-17) https://www.bohe.cn/article/view/8m1kv8feikb9zgo.html
[10] Medical Alliance Media Can children eat bovine spleen peptide [EB/OL]? (May 16, 2023) http://www.yilianmeiti.com/article/454994.html
[11] Zhihu Can spleen peptide enhance immunity? Is bovine spleen peptide an intelligence tax [EB/OL]? (2022-10-31) https://www.zhihu.com/question/563755988
[12] WeChat public platform Cow spleen peptide, the secret weapon for children's growth [EB/OL]. (2022-03-07) https://mp.weixin.qq.com
[13] The Road to Health The role and efficacy of bovine spleen protein peptide [EB/OL]. (2023-10-29) https://m.jkzl.com/doctor/mip/mip_article.html?contentId=8959e32dbe504290d88be3260ab5a013
[14] Dr. Bohe The function and efficacy of bovine spleen peptide [EB/OL]. (2026-04-06) https://www.bohe.cn/ask/view/aijnddoa6ykbir5.html
[15] Milk powder think tank Can invigorating the spleen and stimulating the appetite also enhance immunity? The popularization of bovine spleen peptide has arrived [EB/OL]. (August 12, 2024) https://www.naifenzhiku.com/article/cate-19/detail-20603.html
[16] Yan Meirong, Wang Chaoyang, Su Yilaqimuge, etc The inhibitory effect of bovine spleen peptide on tumor growth in mice with liver cancer [J]. Journal of Inner Mongolia Medical College, 2010, 32 (02): 191-195
[17] Zhang Chuanhao, Guo Jiefu, Li Haitao, etc Research progress and application of small molecule peptides [J]. Chemical Reagents, 2015, 37 (08): 707-710
FAQ
What is bovine spleen good for?
Beef spleen is one of the most nutrient-dense organ meats available, celebrated for its exceptionally high concentration of bioavailable heme iron and immune-supporting properties. It is primarily consumed in traditional dishes or taken as a freeze-dried supplement.
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